Structural plasticity of mini‐M conotoxins – expression of all mini‐M subtypes by Conus regius

Structural plasticity of mini‐M conotoxins – expression of all mini‐M subtypes by Conus regius AbbreviationsBLASTbasic local alignment search toolCDAP1‐cyano‐4‐dimethylamino‐pyridinium tetrafluoroborateCSIchemical shift indexDTTdithiothreitolEDTAethylenediaminetetraacetic acidIAMiodoacetamideMALDI‐TOFmatrix assisted laser desorption ionization time‐of‐flightNOEnuclear Overhauser effectPFGpulse field gradientPTHphenylthiohydantoinPTMposttranslational modificationRFradio frequencyRMSDroot‐mean‐square deviationRPreversed phaseSCUBAself‐contained underwater breading apparatusSEsize exclusionTCEPtris(2‐carboxyethyl)phosphineTFAtrifluoroacetic acidTSP3‐(Trimethylsilyl)‐ Propionic acid‐D4, sodium saltWETwater suppression enhanced through T1 effectsIntroductionVenoms from predatory animals are rich sources of disulfide‐constrained peptides and proteins. Cone snails, a genus of venomous predatory marine mollusks, excel at producing highly modified disulfide‐rich peptidic scaffolds . These slow‐moving animals deploy a proboscis that is tipped with a modified radular tooth used to impale their prey (fish, worms, or mollusks) and deliver their venom. Cone snail venom is a complex concoction of hundreds of compounds that act synergistically to immobilize prey . Conotoxins, venom peptides with two or more disulfides, are highly modified by hydroxylation, carboxylation, bromination, glycosylation, epimerization and combinations of these modifications . These modifications can help to increase conotoxin stability and specificity toward their molecular targets . Conotoxins are classified by superfamilies, which are defined by the conserved signal sequences in the precursor proteins of these peptides. Beyond the superfamilies, conotoxins are further grouped according to their pharmacological targets, which include voltage‐gated ion channels (Na+, K+, and Ca2+) and ligand‐gated ion channels (nAChR, AMPAR, GABAR and 5‐HT3R) .Conotoxins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Febs Journal Wiley

Structural plasticity of mini‐M conotoxins – expression of all mini‐M subtypes by Conus regius

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Federation of European Biochemical Societies
ISSN
1742-464X
eISSN
1742-4658
D.O.I.
10.1111/febs.14372
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsBLASTbasic local alignment search toolCDAP1‐cyano‐4‐dimethylamino‐pyridinium tetrafluoroborateCSIchemical shift indexDTTdithiothreitolEDTAethylenediaminetetraacetic acidIAMiodoacetamideMALDI‐TOFmatrix assisted laser desorption ionization time‐of‐flightNOEnuclear Overhauser effectPFGpulse field gradientPTHphenylthiohydantoinPTMposttranslational modificationRFradio frequencyRMSDroot‐mean‐square deviationRPreversed phaseSCUBAself‐contained underwater breading apparatusSEsize exclusionTCEPtris(2‐carboxyethyl)phosphineTFAtrifluoroacetic acidTSP3‐(Trimethylsilyl)‐ Propionic acid‐D4, sodium saltWETwater suppression enhanced through T1 effectsIntroductionVenoms from predatory animals are rich sources of disulfide‐constrained peptides and proteins. Cone snails, a genus of venomous predatory marine mollusks, excel at producing highly modified disulfide‐rich peptidic scaffolds . These slow‐moving animals deploy a proboscis that is tipped with a modified radular tooth used to impale their prey (fish, worms, or mollusks) and deliver their venom. Cone snail venom is a complex concoction of hundreds of compounds that act synergistically to immobilize prey . Conotoxins, venom peptides with two or more disulfides, are highly modified by hydroxylation, carboxylation, bromination, glycosylation, epimerization and combinations of these modifications . These modifications can help to increase conotoxin stability and specificity toward their molecular targets . Conotoxins are classified by superfamilies, which are defined by the conserved signal sequences in the precursor proteins of these peptides. Beyond the superfamilies, conotoxins are further grouped according to their pharmacological targets, which include voltage‐gated ion channels (Na+, K+, and Ca2+) and ligand‐gated ion channels (nAChR, AMPAR, GABAR and 5‐HT3R) .Conotoxins

Journal

Febs JournalWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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