Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors

Structural, conformational, and stereochemical requirements of central excitatory amino acid... Structural. Conformational. and Stereochemical Requirements of Central Excitatory Amino Acid Receptors Jan J . Hansen and Povl Krogsgaard-Larsen PharmBiofec Research Center. Department of Organic Chemistry. The Royal Danish School of Pharmacy. 2 Universitetsparken. DK-2100 Copenhagen. Denmark I . Introduction ................................................................ I1. Excitatory Amino Acid (EAA) Receptors ............................ A . Receptor classification and function ............................. ...... B . 3xcitotoxicity and pathological effects . . . . . . . . . . . . 1 1. Binciing Studies at EAA Receptors ............................................ 1 A . Binding studies using radiolabeled L-G~u ........................ R . Binding studies at NMDA receptors ....................................... C . binding studies at QUIS/AMPA receptors . . . D. Binding studies at KAIN receptors ......................................... E . Binding studies using radiolabeled AP4 . . . . . . . . . . .......... IV. NMDA Receptor Agonists .................... A . Structural relationships ............................................... 8. Conformational considerations ........................................... C. Stereochemical aspects . . . V. NMDA Receptor Antagonists ................................................. .................................. A . Competitive antagonists . . 8 . Noncompetitive antagonists ............................................... Vl . QUIS/AMPA Receptor Agonists ............... A. Structural relationships ................................................... B . Conformational considerations ............................................ .................................. C. Stereochemical aspects ...... VII . KAIN Receptor Agonists ..................................................... A . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medicinal Research Reviews Wiley

Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors

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Publisher
Wiley
Copyright
Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company
ISSN
0198-6325
eISSN
1098-1128
DOI
10.1002/med.2610100103
Publisher site
See Article on Publisher Site

Abstract

Structural. Conformational. and Stereochemical Requirements of Central Excitatory Amino Acid Receptors Jan J . Hansen and Povl Krogsgaard-Larsen PharmBiofec Research Center. Department of Organic Chemistry. The Royal Danish School of Pharmacy. 2 Universitetsparken. DK-2100 Copenhagen. Denmark I . Introduction ................................................................ I1. Excitatory Amino Acid (EAA) Receptors ............................ A . Receptor classification and function ............................. ...... B . 3xcitotoxicity and pathological effects . . . . . . . . . . . . 1 1. Binciing Studies at EAA Receptors ............................................ 1 A . Binding studies using radiolabeled L-G~u ........................ R . Binding studies at NMDA receptors ....................................... C . binding studies at QUIS/AMPA receptors . . . D. Binding studies at KAIN receptors ......................................... E . Binding studies using radiolabeled AP4 . . . . . . . . . . .......... IV. NMDA Receptor Agonists .................... A . Structural relationships ............................................... 8. Conformational considerations ........................................... C. Stereochemical aspects . . . V. NMDA Receptor Antagonists ................................................. .................................. A . Competitive antagonists . . 8 . Noncompetitive antagonists ............................................... Vl . QUIS/AMPA Receptor Agonists ............... A. Structural relationships ................................................... B . Conformational considerations ............................................ .................................. C. Stereochemical aspects ...... VII . KAIN Receptor Agonists ..................................................... A .

Journal

Medicinal Research ReviewsWiley

Published: Jan 1, 1990

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