IntroductionDrug therapies require the active pharmaceutical ingredients (API) to reach the desired site of action and the success of the treatment is governed by the time the drug requires to reach the target, the amount of drug assembling at the target site as well as its residence time. Furthermore, considerations like administration route, processing, and storage of drug formulations need attention as only the combination of all these allows the achievement of successful medications ready for therapy, marketing, and help for patients. Very often, drug molecules well perform only when assistance from other substances is provided. These substances (i.e., excipients) limit processing issues, mechanical and chemical instabilities, dissolution problems, resorption problems, and poor bio‐availability or assist for better systemic circulation. Hence, the development of new therapeutic options is not limited to the synthesis and screening of new APIs, but also different administration routes and alternative dosage forms are extensively investigated. Generally, the latter is achieved by the engineering and processing of new excipients.Ever since medications were used, excipients are employed. Especially, the usage of macromolecules or polymers as fillers, gliding agent, disintegration agent, or protective coatings allow the preparation of solid state formulations like tablets, pellets, or powders. Developments
Advanced Engineering Materials – Wiley
Published: Jan 1, 2018
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