Stimulation of oligodendrocytes by extracts from astrocyte‐enriched cultures

Stimulation of oligodendrocytes by extracts from astrocyte‐enriched cultures A soluble, heat‐labile, trypson‐sensitive factor present in extracts of astrocyteenriched cultures enhances the expression of myelination‐associated events in rat brain cultures enriched in oligodendrocytes. Both the number of oligodendrocytes detected by immunofluorescence microscopy and the levels of biochemical activities associated with oligodendrocyte differentiation increased in the cultures in respose to the extract in a time‐ and concentration‐dependent fashion. The possible significance of these studies of normal oligodendrocytes function, and thus myelination, is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Research Wiley

Stimulation of oligodendrocytes by extracts from astrocyte‐enriched cultures

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Publisher
Wiley
Copyright
Copyright © 1986 Alan R. Liss, Inc.
ISSN
0360-4012
eISSN
1097-4547
D.O.I.
10.1002/jnr.490150103
Publisher site
See Article on Publisher Site

Abstract

A soluble, heat‐labile, trypson‐sensitive factor present in extracts of astrocyteenriched cultures enhances the expression of myelination‐associated events in rat brain cultures enriched in oligodendrocytes. Both the number of oligodendrocytes detected by immunofluorescence microscopy and the levels of biochemical activities associated with oligodendrocyte differentiation increased in the cultures in respose to the extract in a time‐ and concentration‐dependent fashion. The possible significance of these studies of normal oligodendrocytes function, and thus myelination, is discussed.

Journal

Journal of Neuroscience ResearchWiley

Published: Jan 1, 1986

References

  • Glial and the central myelin sheath
    Bunge, Bunge
  • Noncoordinate regulation of myelinogenic parameters in primary cultures of dissociated fetal brain
    Pfeiffer, Pfeiffer; Barbarese, Barbarese; Bhat, Bhat

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