Steroid potentiation of responses to sympathomimetic amines in aortic strips

Steroid potentiation of responses to sympathomimetic amines in aortic strips 1 Responses to catecholamines (adrenaline, noradrenaline, nordefrine) were enhanced by 17β‐oestradiol, progesterone and desoxycorticosterone in untreated and reserpine pretreated aortic strips. Responses to tyramine, believed mediated via endogenous catecholamines, were enhanced only in untreated strips. 2 Responses to sympathomimetic amines lacking the catechol nucleus (phenylephrine, synephrine, methoxamine) were potentiated inconsistently by the steroids and reserpine pretreatment reduced markedly the frequency of potentiated responses. 3 Known inhibitors of catechol‐O‐methyl transferase (tropolone, U‐0521, pyrogallol) potentiated responses to catecholamines and abolished the enhancing effects of the steroids—when the steroids were given first, there was no further increase in response to catecholamines on adding inhibitors of catechol‐O‐methyl transferase. 4 Experiments with the oil‐immersion technique, to eliminate diffusion of drug from the tissue, indicated that 17β‐oestradiol, progesterone and desoxycorticosterone decreased the rate at which aortic strips inactivated adrenaline by Omethylation. 5 It is concluded that 17β‐oestradiol, progesterone and desoxycorticosterone potentiate responses to catecholamines in aortic strips by inhibiting a major mechanism for their inactivation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Steroid potentiation of responses to sympathomimetic amines in aortic strips

British Journal of Pharmacology, Volume 36 (3) – Jul 1, 1969

Loading next page...
 
/lp/wiley/steroid-potentiation-of-responses-to-sympathomimetic-amines-in-aortic-9obarlZaAh
Publisher
Wiley
Copyright
1969 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
D.O.I.
10.1111/j.1476-5381.1969.tb08013.x
Publisher site
See Article on Publisher Site

Abstract

1 Responses to catecholamines (adrenaline, noradrenaline, nordefrine) were enhanced by 17β‐oestradiol, progesterone and desoxycorticosterone in untreated and reserpine pretreated aortic strips. Responses to tyramine, believed mediated via endogenous catecholamines, were enhanced only in untreated strips. 2 Responses to sympathomimetic amines lacking the catechol nucleus (phenylephrine, synephrine, methoxamine) were potentiated inconsistently by the steroids and reserpine pretreatment reduced markedly the frequency of potentiated responses. 3 Known inhibitors of catechol‐O‐methyl transferase (tropolone, U‐0521, pyrogallol) potentiated responses to catecholamines and abolished the enhancing effects of the steroids—when the steroids were given first, there was no further increase in response to catecholamines on adding inhibitors of catechol‐O‐methyl transferase. 4 Experiments with the oil‐immersion technique, to eliminate diffusion of drug from the tissue, indicated that 17β‐oestradiol, progesterone and desoxycorticosterone decreased the rate at which aortic strips inactivated adrenaline by Omethylation. 5 It is concluded that 17β‐oestradiol, progesterone and desoxycorticosterone potentiate responses to catecholamines in aortic strips by inhibiting a major mechanism for their inactivation.

Journal

British Journal of PharmacologyWiley

Published: Jul 1, 1969

References

  • Effects of a haloalkylamine on responses to and disposition of sympathomimetic amines
    Kalsner, Kalsner; Nickerson, Nickerson

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off