Stereoselective effects of AMOA on non‐NMDA receptors expressed in Xenopus Oocytes

Stereoselective effects of AMOA on non‐NMDA receptors expressed in Xenopus Oocytes Pharmacological characterization of the action of the novel non‐N‐methyl‐D‐aspartate non‐NMDA) antagonist AMOA (2‐amino‐3‐(3‐ (carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionate on glutamate receptors was investigated in Xenopus ooccytes injected with mouse brain mRNA. AMOA (150 μM) produced a nearly parallel shift to the right of the dose‐response curve for kainate‐induced currents. AMOA was found to have two different effects on AMPA receptors: (1) currents elicited by low concentrations of AMPA (6 μM) were inhibited by AMOA with an IC50 value of 160 ± 19 μM and (2) currents elicited by high concentrations of AMPA (100 μM) were potentiated with an IC50 value of 88 ± 22 μM. The maximal potentiating effect of AMOA on AMPA currents was around 170%. Furthermore, the two opposing effects of AMOA on AMPA responses are specific for the L‐configuration of AMOA. This unusual antagonistic/agonistic property of AMOA may explain its unusual properties with regard to antagonism of non‐NMDA receptor‐mediated events previously described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Research Wiley

Stereoselective effects of AMOA on non‐NMDA receptors expressed in Xenopus Oocytes

Loading next page...
 
/lp/wiley/stereoselective-effects-of-amoa-on-non-nmda-receptors-expressed-in-f2YSzQEdh0
Publisher
Wiley
Copyright
Copyright © 1992 Wiley‐Liss, Inc.
ISSN
0360-4012
eISSN
1097-4547
DOI
10.1002/jnr.490330305
pmid
1281890
Publisher site
See Article on Publisher Site

Abstract

Pharmacological characterization of the action of the novel non‐N‐methyl‐D‐aspartate non‐NMDA) antagonist AMOA (2‐amino‐3‐(3‐ (carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionate on glutamate receptors was investigated in Xenopus ooccytes injected with mouse brain mRNA. AMOA (150 μM) produced a nearly parallel shift to the right of the dose‐response curve for kainate‐induced currents. AMOA was found to have two different effects on AMPA receptors: (1) currents elicited by low concentrations of AMPA (6 μM) were inhibited by AMOA with an IC50 value of 160 ± 19 μM and (2) currents elicited by high concentrations of AMPA (100 μM) were potentiated with an IC50 value of 88 ± 22 μM. The maximal potentiating effect of AMOA on AMPA currents was around 170%. Furthermore, the two opposing effects of AMOA on AMPA responses are specific for the L‐configuration of AMOA. This unusual antagonistic/agonistic property of AMOA may explain its unusual properties with regard to antagonism of non‐NMDA receptor‐mediated events previously described.

Journal

Journal of Neuroscience ResearchWiley

Published: Nov 1, 1992

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off