Pharmacological characterization of the action of the novel non‐N‐methyl‐D‐aspartate non‐NMDA) antagonist AMOA (2‐amino‐3‐(3‐ (carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionate on glutamate receptors was investigated in Xenopus ooccytes injected with mouse brain mRNA. AMOA (150 μM) produced a nearly parallel shift to the right of the dose‐response curve for kainate‐induced currents. AMOA was found to have two different effects on AMPA receptors: (1) currents elicited by low concentrations of AMPA (6 μM) were inhibited by AMOA with an IC50 value of 160 ± 19 μM and (2) currents elicited by high concentrations of AMPA (100 μM) were potentiated with an IC50 value of 88 ± 22 μM. The maximal potentiating effect of AMOA on AMPA currents was around 170%. Furthermore, the two opposing effects of AMOA on AMPA responses are specific for the L‐configuration of AMOA. This unusual antagonistic/agonistic property of AMOA may explain its unusual properties with regard to antagonism of non‐NMDA receptor‐mediated events previously described.
Journal of Neuroscience Research – Wiley
Published: Nov 1, 1992
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera