CONTENTS I. Introduction PAGE PAGE (3) Mechanism involving backside attack by a group in the substrate molecule . 11. Mechanisms of non-enzymatic substitution reactions . . 111. Enzymatic reactions proceeding with retention of configuration . . V. Enzymatic reactions proceeding with inversion. VI. Nomenclature IV. Mechanism of the reactions pro. ceeding with retention . ( I ) Mechanism involving only apparent replacement at the (2) . . . VII. Relationship to other enzymatic substitution reactions . . ~ 1 1 1 .summaq . asymmetric atom . . . Mechanism involving an enzyme-substrate intermediate . IX. References I. INTRODUCTION T h e isolation and purification of an enzyme makes it possible to consider the reaction which it catalyses from the standpoint of organic chemistry; it can be considered as a reaction between organic molecules in which the catalyst happens to be a protein. Such a consideration allows the tools of physical organic chemistry to be applied to the study of the enzyme mechanism, and, since a number of enzymes have been purified, to obtain correlations of what might otherwise appear to be unrelated processes. One of the particularly powerful tools used in the elucidation of chemical mechanisms is stereochemistry,
Biological Reviews – Wiley
Published: Nov 1, 1953
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