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H. Dolk, M. Seller (1993)
Neural tube defects: a survey of lesion descriptions made by different European pathologists.Journal of Medical Genetics, 30
B. Garabedian, F. Fraser (1993)
Upper and lower neural tube defects: an alternate hypothesis.Journal of Medical Genetics, 30
C. Shaer, N. Chescheir, J. Schulkin (2007)
Myelomeningocele: A Review of the Epidemiology, Genetics, Risk Factors for Conception, Prenatal Diagnosis, and Prognosis for Affected IndividualsObstetrical & Gynecological Survey, 62
Elaine Drainer, Heather May, J. Tolmie (1991)
Do familial neural tube defects breed true?Journal of Medical Genetics, 28
E. Mariman, B. Hamel (1992)
Sex ratios of affected and transmitting members of multiple case families with neural tube defects.Journal of Medical Genetics, 29
A. Hori (2004)
A review of the morphology of spinal cord malformations and their relation to neuro-embryologyNeurosurgical Review, 16
T. Sadler (2005)
Embryology of neural tube developmentAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, 135C
J. Stockman (2009)
Reduction in Neural-Tube Defects after Folic Acid Fortification in CanadaYearbook of Pediatrics, 2009
M. Allen, D. Kalousek, Gerold Chernoff, D. Juriloff, M. Harris, B. Mcgillivray, S. Yong, S. Langlois, P. Macleod, D. Chitayat, J. Friedman, R. Wilson, D. McFadden, J. Pantzar, S. Ritchie, J. Hall (1993)
Evidence for multi-site closure of the neural tube in humans.American journal of medical genetics, 47 5
Marketplace Services, Corporations Canada (2001)
Regulatory impact analysis statement – Amendments to the Canada Cooperatives Regulations
(1992)
Geographical variation
De Wals (2007)
Reduction in neural-tube defects after folic acid fortification in CanadaN Engl J Med, 357
H. Dolk, P. Wals, Yves Gillerot, M. Lechat, Ségolène Aymé, M. Cornel, A. Cuschieri, E. Garne, J. Goujard, K. Laurence, D. Lillis, F. Lys, Norman Nevin, J. Owens, A. Radic, C. Stoll, David Stone, L. Kate (1991)
Heterogeneity of neural tube defects in Europe: the significance of site of defect and presence of other major anomalies in relation to geographic differences in prevalence.Teratology, 44 5
中津 智子 (2000)
Neural tube closure in humans initiates at multiple sites : Evidence from human embryos and implications for the Pathogenesis of neural tube defects
H. Dolk (1991)
Prevalence of neural tube defects in 20 regions of Europe and the impact of prenatal diagnosis, 1980-1986. EUROCAT Working Group.Journal of Epidemiology and Community Health, 45
Canada (1998)
Regulatory impact analysis statementSOR/98-550 Part II., 132
A. Barson (1970)
Spina Bifida: The Significance of the Level and Extent of the Defect to the MorphogenesisDevelopmental Medicine & Child Neurology, 12
B. Blatter, A. Lafeber, P. Peters, N. Roeleveld, A. Verbeek, F. Gabreëls (1997)
Heterogeneity of spina bifida.Teratology, 55 4
A. Hunter, R. Cleveland, J. Blickman, L. Holmes (1996)
A study of level of lesion, associated malformations and sib occurrence risks in spina bifida.Teratology, 54 5
M. Seller (1995)
Sex, neural tube defects, and multisite closure of the human neural tube.American journal of medical genetics, 58 4
P. Wals, C. Trochet, L. Pinsonneault (1999)
Prevalence of Neural Tube Defects in the Province of Quebec, 1992Canadian Journal of Public Health, 90
H. Toriello, H. Toriello, James Higgins, John Opitz, J. Reynolds (1985)
Possible causal heterogeneity in spina bifida cystica.American journal of medical genetics, 21 1
J. Ray, M. Vermeulen, S. Boss, D. Cole (2002)
Declining Rate of Folate Insufficiency Among Adults Following Increased Folic Acid Food Fortification in CanadaCanadian Journal of Public Health, 93
M. Martínez‐Frías, M. Urioste, E. Bermejo, A. Sanchis, E. Rodríguez‐Pinilla (1996)
Epidemiological analysis of multi-site closure failure of neural tube in humans.American journal of medical genetics, 66 1
Fassiatou Tairou, P. Wals, A. Bastide (2006)
Validity of death and stillbirth certificates and hospital discharge summaries for the identification of neural tube defects in Quebec City.Chronic diseases in Canada, 27 3
R. O'rahilly, F. Müller (2002)
The two sites of fusion of the neural folds and the two neuropores in the human embryo.Teratology, 65 4
Christina Park, Walter Stewart, Muin Khoury, Joseph Mulinare (1992)
Is there etiologic heterogeneity between upper and lower neural tube defects?American journal of epidemiology, 136 12
(1997)
Heterogeneity of spina
L. Botto, C. Moore, M. Khoury, J. Erickson (1999)
Neural-tube defects.The New England journal of medicine, 341 20
BACKGROUND: In 1998, fortification of a large variety of cereal products with folic acid became mandatory in Canada. A multicentric study was carried out to assess the impact of this policy on the frequency of NTDs. The present analysis focused on spina bifida. METHODS: The study population included approximately 2 million livebirths, stillbirths, and terminations of pregnancies because of fetal anomalies among women residing in seven Canadian provinces, from 1993 to 2002. Spina bifida cases were divided according to the upper limit of the defect: upper (cranial, cervical, or thoracic) and lower (lumbar or sacral) defects. Based on published results of red blood cell folate tests, the study period was divided into prefortification, partial fortification, and full fortification periods. RESULTS: A total of 1,286 spina bifida cases were identified: 51% livebirths, 3% stillbirths, and 46% terminations. Prevalence decreased from 0.86/1,000 in the prefortification to 0.40 in the full fortification period, while the proportion of upper defects decreased from 32% to 13%. Following fortification, regional variations in the prevalence and distribution of sites almost disappeared. CONCLUSIONS: Results confirmed the etiologic heterogeneity of spina bifida and the more pronounced effect of folic acid in decreasing the risk of the more severe clinical presentations. Birth Defects Research (Part A) 2008. © 2008 Wiley‐Liss, Inc.
Birth Defects Research Part A – Wiley
Published: Sep 1, 2008
Keywords: fortification; food; folic acid; spina bifida; neural tube defect; program evaluation
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