Specific Inhibition of Dopamine D‐1‐Mediated Cyclic AMP Formation by Dopamine D‐2, Muscarinic Cholinergic, and Opiate Receptor Stimulation in Rat Striatal Slices

Specific Inhibition of Dopamine D‐1‐Mediated Cyclic AMP Formation by Dopamine D‐2,... Abstract The ability of different receptors to mediate inhibition of cyclic AMP accumulation due to a variety of agonists was examined in rat striatal slices. In the presence of 1 mM 3‐isobutyl‐1‐metbylxanthine, dopamine D‐2, muscarinic cholinergic, and opiate receptor stimulation by RU 24926, carbachol, and morphine (all at 10−‐8‐−1(10−‐5M), respectively, inhibited the increase in cyclic AMP accumulation in slices of rat striatum due to dopamine D‐1 receptor stimulation by 1 μM SKF 38393. In contrast, these inhibitory agents were unable to reduce the ability of a number of other agonists, including isoprenaline, prostaglandin E1, 2‐chloroadenosine, vasoactive intestinal polypeptide, and cholera toxin, to increase cyclic AMP levels in striatal slices. These results suggest that in rat striatum either (a) dopamine D‐2, muscarinic cholinergic, and opiate receptors are only functionally linked to dopamine D‐l receptors or that (b) the D‐1 and D‐2 receptors linked to adenylate cyclase lie on the cells, distinct from other receptors capable of elevating striatal cyclic AMP levels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Specific Inhibition of Dopamine D‐1‐Mediated Cyclic AMP Formation by Dopamine D‐2, Muscarinic Cholinergic, and Opiate Receptor Stimulation in Rat Striatal Slices

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Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1986.tb00787.x
Publisher site
See Article on Publisher Site

Abstract

Abstract The ability of different receptors to mediate inhibition of cyclic AMP accumulation due to a variety of agonists was examined in rat striatal slices. In the presence of 1 mM 3‐isobutyl‐1‐metbylxanthine, dopamine D‐2, muscarinic cholinergic, and opiate receptor stimulation by RU 24926, carbachol, and morphine (all at 10−‐8‐−1(10−‐5M), respectively, inhibited the increase in cyclic AMP accumulation in slices of rat striatum due to dopamine D‐1 receptor stimulation by 1 μM SKF 38393. In contrast, these inhibitory agents were unable to reduce the ability of a number of other agonists, including isoprenaline, prostaglandin E1, 2‐chloroadenosine, vasoactive intestinal polypeptide, and cholera toxin, to increase cyclic AMP levels in striatal slices. These results suggest that in rat striatum either (a) dopamine D‐2, muscarinic cholinergic, and opiate receptors are only functionally linked to dopamine D‐l receptors or that (b) the D‐1 and D‐2 receptors linked to adenylate cyclase lie on the cells, distinct from other receptors capable of elevating striatal cyclic AMP levels.

Journal

Journal of NeurochemistryWiley

Published: Nov 1, 1986

References

  • Multiple receptors for dopamine
    Kebabian, Kebabian; Calne, Calne
  • Muscarinic receptors modulate dopamine‐activated adenylate cyclase of rat striatum
    Olianas, Olianas; Onali, Onali; Neff, Neff; Costa, Costa

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