Abstract The ability of different receptors to mediate inhibition of cyclic AMP accumulation due to a variety of agonists was examined in rat striatal slices. In the presence of 1 mM 3‐isobutyl‐1‐metbylxanthine, dopamine D‐2, muscarinic cholinergic, and opiate receptor stimulation by RU 24926, carbachol, and morphine (all at 10−‐8‐−1(10−‐5M), respectively, inhibited the increase in cyclic AMP accumulation in slices of rat striatum due to dopamine D‐1 receptor stimulation by 1 μM SKF 38393. In contrast, these inhibitory agents were unable to reduce the ability of a number of other agonists, including isoprenaline, prostaglandin E1, 2‐chloroadenosine, vasoactive intestinal polypeptide, and cholera toxin, to increase cyclic AMP levels in striatal slices. These results suggest that in rat striatum either (a) dopamine D‐2, muscarinic cholinergic, and opiate receptors are only functionally linked to dopamine D‐l receptors or that (b) the D‐1 and D‐2 receptors linked to adenylate cyclase lie on the cells, distinct from other receptors capable of elevating striatal cyclic AMP levels.
Journal of Neurochemistry – Wiley
Published: Nov 1, 1986
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