Specific Binding of ( 11 C)Spiroperidol in Rat Brain In Vivo

Specific Binding of ( 11 C)Spiroperidol in Rat Brain In Vivo Abstract: Spiroperidol labeled with carbon‐11, a shortlived positron‐emitting radionuclide, was used to determine the time course of specific binding of this radio‐ligand to the neuroleptic receptor in vivo in the rat. The three major brain pools‐specifically bound, non‐specifically bound and free (unbound)‐were determined over a 60‐min time course by a rapid filtration technique, utilizing (‐)‐ and (+)‐butaclamol pretreatments to assess total and nonspecifically bound activities, respectively, in striatum and cerebellum. The ratio of specifically to nonspecifically bound pools in the striatum was 4.1 at 30 min and 5.1 at 60 min. Thus (11C)spiroperidol may be useful for labeling neuroleptic receptors in vivo for serial studies using positron emission transaxial tomography. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Specific Binding of ( 11 C)Spiroperidol in Rat Brain In Vivo

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Publisher
Wiley
Copyright
Copyright © 1983 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1983.tb11304.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Spiroperidol labeled with carbon‐11, a shortlived positron‐emitting radionuclide, was used to determine the time course of specific binding of this radio‐ligand to the neuroleptic receptor in vivo in the rat. The three major brain pools‐specifically bound, non‐specifically bound and free (unbound)‐were determined over a 60‐min time course by a rapid filtration technique, utilizing (‐)‐ and (+)‐butaclamol pretreatments to assess total and nonspecifically bound activities, respectively, in striatum and cerebellum. The ratio of specifically to nonspecifically bound pools in the striatum was 4.1 at 30 min and 5.1 at 60 min. Thus (11C)spiroperidol may be useful for labeling neuroleptic receptors in vivo for serial studies using positron emission transaxial tomography.

Journal

Journal of NeurochemistryWiley

Published: Feb 1, 1983

References

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