Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections

Species differences in circulation and inflammatory responses in children with common respiratory... INTRODUCTIONFamily Adenoviridae, genus Adenovirus, human adenovirus types (HAdVs) are known to cause strong inflammatory responses, such as elevation of the white blood cell (WBC) count and C‐reactive protein (CRP), which sometimes leads to overuse of antibiotics. Differences in the immune responses to the various species of HAdV have not been well studied. Links between epidemiology and immune responses may provide clues to understanding the mechanisms underlying HAdVs' circulation patterns.Although HAdVs are one of the most common pathogens in young children, accounting for 10‐29% of upper respiratory infections, the diseases they cause are believed to be mild and self‐limiting. However, HAdVs sometimes cause outbreaks of severe disease not only in children, but also in adults. Understanding the circulation patterns of and inflammatory responses to HAdV in healthy children might have epidemiological significance since virus circulating in the normal population may serve as a reservoir for outbreaks. There have been, however, no reports that investigated community‐based epidemiology, including inflammatory testing for common HAdV respiratory disease in children.To address the above issue, we conducted a prospective study aimed at clarifying the circulation patterns and clinical/laboratory features of respiratory HAdV infections in children at a primary care clinic in a small community. Their http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25032
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONFamily Adenoviridae, genus Adenovirus, human adenovirus types (HAdVs) are known to cause strong inflammatory responses, such as elevation of the white blood cell (WBC) count and C‐reactive protein (CRP), which sometimes leads to overuse of antibiotics. Differences in the immune responses to the various species of HAdV have not been well studied. Links between epidemiology and immune responses may provide clues to understanding the mechanisms underlying HAdVs' circulation patterns.Although HAdVs are one of the most common pathogens in young children, accounting for 10‐29% of upper respiratory infections, the diseases they cause are believed to be mild and self‐limiting. However, HAdVs sometimes cause outbreaks of severe disease not only in children, but also in adults. Understanding the circulation patterns of and inflammatory responses to HAdV in healthy children might have epidemiological significance since virus circulating in the normal population may serve as a reservoir for outbreaks. There have been, however, no reports that investigated community‐based epidemiology, including inflammatory testing for common HAdV respiratory disease in children.To address the above issue, we conducted a prospective study aimed at clarifying the circulation patterns and clinical/laboratory features of respiratory HAdV infections in children at a primary care clinic in a small community. Their

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

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References

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