SOX10/keratin dual‐color immunohistochemistry: An effective first‐line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens

SOX10/keratin dual‐color immunohistochemistry: An effective first‐line test for the workup of... INTRODUCTIONThe timely and accurate diagnosis of poorly differentiated epithelioid neoplasms often is challenging due to a broad differential diagnosis that includes melanoma, carcinoma, and certain sarcomas with an epithelioid morphology. Thus, a panel of immunohistochemical stains covering several lineages of differentiation often is required for the precise classification of these tumors. This is especially true in the 3% to 5% of patients who present with cancer of an unknown primary site, or the growing population of patients with a history of multiple primary malignancies. As an increasing number of predictive tests for specific drugs and molecular assays have entered into routine clinical practice, the preservation of limited biopsy material is of paramount importance to identify potential targeted therapies, establish eligibility for immune checkpoint inhibitor therapy, or to allow a patient to enroll in a clinical trial. Moreover, as reimbursement structures change, rapid and accurate diagnoses that preserve limited material by minimizing the number of immunohistochemical stains – while reducing the number of biopsies specifically designated for obtaining tissue for ancillary studies – will become more important.Dual‐color immunohistochemistry (IHC) has been established as an adjunct test for the evaluation of invasive carcinoma in both the breast and prostate, and has http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Cytopathology Wiley

SOX10/keratin dual‐color immunohistochemistry: An effective first‐line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 American Cancer Society
ISSN
1934-662X
eISSN
1934-6638
D.O.I.
10.1002/cncy.21960
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe timely and accurate diagnosis of poorly differentiated epithelioid neoplasms often is challenging due to a broad differential diagnosis that includes melanoma, carcinoma, and certain sarcomas with an epithelioid morphology. Thus, a panel of immunohistochemical stains covering several lineages of differentiation often is required for the precise classification of these tumors. This is especially true in the 3% to 5% of patients who present with cancer of an unknown primary site, or the growing population of patients with a history of multiple primary malignancies. As an increasing number of predictive tests for specific drugs and molecular assays have entered into routine clinical practice, the preservation of limited biopsy material is of paramount importance to identify potential targeted therapies, establish eligibility for immune checkpoint inhibitor therapy, or to allow a patient to enroll in a clinical trial. Moreover, as reimbursement structures change, rapid and accurate diagnoses that preserve limited material by minimizing the number of immunohistochemical stains – while reducing the number of biopsies specifically designated for obtaining tissue for ancillary studies – will become more important.Dual‐color immunohistochemistry (IHC) has been established as an adjunct test for the evaluation of invasive carcinoma in both the breast and prostate, and has

Journal

Cancer CytopathologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ; ;

References

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