INTRODUCTIONThe timely and accurate diagnosis of poorly differentiated epithelioid neoplasms often is challenging due to a broad differential diagnosis that includes melanoma, carcinoma, and certain sarcomas with an epithelioid morphology. Thus, a panel of immunohistochemical stains covering several lineages of differentiation often is required for the precise classification of these tumors. This is especially true in the 3% to 5% of patients who present with cancer of an unknown primary site, or the growing population of patients with a history of multiple primary malignancies. As an increasing number of predictive tests for specific drugs and molecular assays have entered into routine clinical practice, the preservation of limited biopsy material is of paramount importance to identify potential targeted therapies, establish eligibility for immune checkpoint inhibitor therapy, or to allow a patient to enroll in a clinical trial. Moreover, as reimbursement structures change, rapid and accurate diagnoses that preserve limited material by minimizing the number of immunohistochemical stains – while reducing the number of biopsies specifically designated for obtaining tissue for ancillary studies – will become more important.Dual‐color immunohistochemistry (IHC) has been established as an adjunct test for the evaluation of invasive carcinoma in both the breast and prostate, and has
Cancer Cytopathology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera