Stephanie Bingham1, Aidas Nasevicius2, Stephen C. Ekker2, and Anand Chandrasekhar1, Division of Biological Sciences, University of Missouri, Columbia, Missouri, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota Received 1 May 2001; Accepted 12 June 2001 Published online 23 July 2001; DOI 10.1002/gene.1057 The secreted molecule sonic hedgehog (Shh) is essential for many developmental processes in vertebrates, including the induction of motor neurons (reviewed in Ingham, 1998; Wicking et al., 1999). Three hedgehog genes, shh (Krauss et al., 1993), tiggy-winkle hedgehog (twhh; Ekker et al., 1995) and echidna hedgehog (ehh; Currie and Ingham, 1996) are expressed in various tissues in zebraï¬sh embryos. However, only mutations in shh have been identiï¬ed thus far (Schauerte et al., 1998). Therefore, the precise roles of the three zebraï¬sh hedgehog genes in inducing particular cell types such as motor neurons remain unclear (Beattie et al., 1997; Chandrasekhar et al., 1998). We showed previously that embryos homozygous for a deletion of shh (Schauerte et al., 1998) exhibit characteristic deï¬cits in branchiomotor neuron (BMN) populations in the zebraï¬sh hindbrain (Chandrasekhar et al., 1998). We now demonstrate that knockdown of shh function by morpholino (MO) injection phenocopies the shh loss-of-function motor neuron phenotype.
Genesis: the Journal of Genetics and Development – Wiley
Published: Jul 1, 2001
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