Snapshot‐CEST: Optimizing spiral‐centric‐reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Snapshot‐CEST: Optimizing spiral‐centric‐reordered gradient echo acquisition for fast and... Gradient echo (GRE)‐based acquisition provides a robust readout method for chemical exchange saturation transfer (CEST) at ultrahigh field (UHF). To develop a snapshot‐CEST approach, the transient GRE signal and point spread function were investigated in detail, leading to optimized measurement parameters and reordering schemes for fast and robust volumetric CEST imaging. Simulation of the transient GRE signal was used to determine the optimal sequence parameters and the maximum feasible number of k‐space lines. Point spread function analysis provided an insight into the induced k‐space filtering and the performance of different rectangular reordering schemes in terms of blurring, signal‐to‐noise ratio (SNR) and relaxation dependence. Simulation results were confirmed in magnetic resonance imaging (MRI) measurements of healthy subjects. Minimal repetition time (TR) is beneficial for snapshot‐GRE readout. At 9.4 T, for TR = 4 ms and optimal flip angle close to the Ernst angle, a maximum of 562 k‐space lines can be acquired after a single presaturation, providing decent SNR with high image quality. For spiral‐centric reordered k‐space acquisition, the image quality can be further improved using a rectangular spiral reordering scheme adjusted to the field of view. Application of the derived snapshot‐CEST sequence for fast imaging acquisition in the human brain at 9.4 T shows excellent image quality in amide and nuclear Overhauser enhancement (NOE), and enables guanidyl CEST detection. The proposed snapshot‐CEST establishes a fast and robust volumetric CEST approach ready for the imaging of known and novel exchange‐weighted contrasts at UHF. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png NMR in Biomedicine (Electronic) Wiley

Snapshot‐CEST: Optimizing spiral‐centric‐reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Loading next page...
 
/lp/wiley/snapshot-cest-optimizing-spiral-centric-reordered-gradient-echo-6p95kkQvia
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons, Ltd.
ISSN
0952-3480
eISSN
1099-1492
D.O.I.
10.1002/nbm.3879
Publisher site
See Article on Publisher Site

Abstract

Gradient echo (GRE)‐based acquisition provides a robust readout method for chemical exchange saturation transfer (CEST) at ultrahigh field (UHF). To develop a snapshot‐CEST approach, the transient GRE signal and point spread function were investigated in detail, leading to optimized measurement parameters and reordering schemes for fast and robust volumetric CEST imaging. Simulation of the transient GRE signal was used to determine the optimal sequence parameters and the maximum feasible number of k‐space lines. Point spread function analysis provided an insight into the induced k‐space filtering and the performance of different rectangular reordering schemes in terms of blurring, signal‐to‐noise ratio (SNR) and relaxation dependence. Simulation results were confirmed in magnetic resonance imaging (MRI) measurements of healthy subjects. Minimal repetition time (TR) is beneficial for snapshot‐GRE readout. At 9.4 T, for TR = 4 ms and optimal flip angle close to the Ernst angle, a maximum of 562 k‐space lines can be acquired after a single presaturation, providing decent SNR with high image quality. For spiral‐centric reordered k‐space acquisition, the image quality can be further improved using a rectangular spiral reordering scheme adjusted to the field of view. Application of the derived snapshot‐CEST sequence for fast imaging acquisition in the human brain at 9.4 T shows excellent image quality in amide and nuclear Overhauser enhancement (NOE), and enables guanidyl CEST detection. The proposed snapshot‐CEST establishes a fast and robust volumetric CEST approach ready for the imaging of known and novel exchange‐weighted contrasts at UHF.

Journal

NMR in Biomedicine (Electronic)Wiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off