INTRODUCTIONMolecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. The current guideline from the College of American Pathologists (CAP), International Association for the Study of Lung Cancer (IASLC), and Association for Molecular Pathology (AMP) recommends that patients should be tested regardless of age, race, and smoking history. Fine‐needle aspiration (FNA) is commonly considered as the first diagnostic procedure and FNA‐derived material is frequently the only pathologic material available for morphologic diagnosis, immunohistochemistry, and molecular studies. It is especially in these instances that cytology material becomes extremely valuable for patient management.Likewise, in patients with thyroid nodules, FNA is an integral part of the clinical assessment as defined by the American Thyroid Association guidelines due to its high sensitivity and specificity. Although the diagnosis and management of benign and malignant nodules usually is not problematic, nodules classified as follicular lesions of undetermined significance/atypia of undetermined significance (FLUS/AUS; Bethesda category III are challenging for both the cytopathologist and clinician. Approximately one‐third of the FNA specimens in the suspicious for follicular neoplasm
Cancer Cytopathology – Wiley
Published: Jan 1, 2018
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