Should measures be taken to reduce the risk of human parvovirus (B 19) infection by transfusion of blood components and clotting factor concentrates? Over the last several years, a seemingly endless array of infectious agents have occasionally been transmitted by blood components andor plasma derivatives. We had thought that human parvovirus (HPV, B19) was responsible only for a self-limited common childhoodexanthem, with a brief period of viremia. It is now known to be a virus that is capable of prolonged viremia,' latency with reactivation,2and possible reinfe~tion.~.~ proporA small tion of persons have serious, sometimes chronic, impaired production of erythroid and, sporadically, other bone marrow cells, as well as manifestations in other systems. In this issue of TRANSFUSION, Luban5makes clear that a great deal can be learned quickly about a virus and its pathogenesis by using the tools of molecular virology. She correctly points out how much more difficult is the definition of the type and variety of recipients for whom HPV infection has the potential to be clinically important. Definition of the number of serious acute and chronic HPV cases, particularly if they are sporadic, depends first upon the physician's being aware of the possible diagnosis. In addition,
Transfusion – Wiley
Published: Sep 1, 1994
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