Short‐term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study

Short‐term effect of preoperative intravenous iron therapy in colorectal cancer patients with... ABBREVIATIONSAIDabsolute iron deficiencyASAAmerican Society of AnesthesiologistsFIDfunctional iron deficiencyIDiron deficiencyPBMpatient blood managementUCusual careColorectal cancer is the third most commonly diagnosed cancer in men and second in women worldwide, and patients present with anemia in up to one‐third of the cases. Anemia in this respect is emerging as an important health problem. It is not only associated with fatigue and impaired physical performance and cognitive function, but most importantly also with increased morbidity and mortality.Iron deficiency (ID) is the most common cause of preoperative anemia in colorectal cancer patients. Contributing mechanisms to the development of ID anemia include chronic tumor‐induced blood loss and also impaired iron homeostasis associated with chronic disease. While chronic blood loss will cause absolute ID (AID), characterized by depleted iron stores, impaired iron homeostasis will cause functional ID (FID), characterized by reduced iron uptake and iron mobilization from the reticuloendothelial system, both leading to a reduction of biologically available iron for erythropoiesis.Enhancement of a patient's condition before surgery has been gaining attention ever since the beneficial outcomes of such protocols were shown. More specifically, normalization of preoperative hemoglobin (Hb) level by blood management strategy is an important element in this spectrum of preoperative care.The high prevalence of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Short‐term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study

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Publisher
Wiley
Copyright
© 2018 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1111/trf.14456
Publisher site
See Article on Publisher Site

Abstract

ABBREVIATIONSAIDabsolute iron deficiencyASAAmerican Society of AnesthesiologistsFIDfunctional iron deficiencyIDiron deficiencyPBMpatient blood managementUCusual careColorectal cancer is the third most commonly diagnosed cancer in men and second in women worldwide, and patients present with anemia in up to one‐third of the cases. Anemia in this respect is emerging as an important health problem. It is not only associated with fatigue and impaired physical performance and cognitive function, but most importantly also with increased morbidity and mortality.Iron deficiency (ID) is the most common cause of preoperative anemia in colorectal cancer patients. Contributing mechanisms to the development of ID anemia include chronic tumor‐induced blood loss and also impaired iron homeostasis associated with chronic disease. While chronic blood loss will cause absolute ID (AID), characterized by depleted iron stores, impaired iron homeostasis will cause functional ID (FID), characterized by reduced iron uptake and iron mobilization from the reticuloendothelial system, both leading to a reduction of biologically available iron for erythropoiesis.Enhancement of a patient's condition before surgery has been gaining attention ever since the beneficial outcomes of such protocols were shown. More specifically, normalization of preoperative hemoglobin (Hb) level by blood management strategy is an important element in this spectrum of preoperative care.The high prevalence of

Journal

TransfusionWiley

Published: Jan 1, 2018

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