Serum specific‐IgE antibodies to peptides detected in a casein hydrolysate formula

Serum specific‐IgE antibodies to peptides detected in a casein hydrolysate formula Up to 2. 59% of infants are affected by cow milk hypersensitivity in the first two years of life, although most of these children will “outgrow” their reactivity within 2‐3 years. Extensively hydrolyzed (“hypoallergenic”) cow milk‐based formulae are often recommended as a substitute formula and are generally well tolerated. However, a small minority of cow milk‐allergic children experience allergic reactions to the hypoallergenic formulae as well. Utilizing inhibition‐ELISAs and sera from patients with IgE‐mediated cow milk allergy, we have identified residual protein fractions less than 20 kD in several of the extensively hydrolyzed cow milk‐based formulae. Although many of the cow milk allergic children had positive skin prick lests (SPT) to one of the hydrolysate formulae (Nutramigenma), the positive skin test result generally did not correlate with clinical reactivity, although the negative predictive value of the negative SPT was excellent. Children with IgE‐mediated cow milk allergy and a positive skin prick test to the hypoallergenic formula should probably receive their first dose of the formula in a medical setting so that appropriate therapy can be administered in the unlikely event of an allergic reaction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Serum specific‐IgE antibodies to peptides detected in a casein hydrolysate formula

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Publisher
Wiley
Copyright
Copyright © 1997 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1997.tb00158.x
Publisher site
See Article on Publisher Site

Abstract

Up to 2. 59% of infants are affected by cow milk hypersensitivity in the first two years of life, although most of these children will “outgrow” their reactivity within 2‐3 years. Extensively hydrolyzed (“hypoallergenic”) cow milk‐based formulae are often recommended as a substitute formula and are generally well tolerated. However, a small minority of cow milk‐allergic children experience allergic reactions to the hypoallergenic formulae as well. Utilizing inhibition‐ELISAs and sera from patients with IgE‐mediated cow milk allergy, we have identified residual protein fractions less than 20 kD in several of the extensively hydrolyzed cow milk‐based formulae. Although many of the cow milk allergic children had positive skin prick lests (SPT) to one of the hydrolysate formulae (Nutramigenma), the positive skin test result generally did not correlate with clinical reactivity, although the negative predictive value of the negative SPT was excellent. Children with IgE‐mediated cow milk allergy and a positive skin prick test to the hypoallergenic formula should probably receive their first dose of the formula in a medical setting so that appropriate therapy can be administered in the unlikely event of an allergic reaction.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Nov 1, 1997

References

  • A prospective study of cow milk allergy in Danish infants during the first 3 years of life
    Host, Host; Halken, Halken
  • Application of an electrophoretic methodology for the identification of low molecular weight proteins in foods
    Dean, Dean; Clarke, Clarke; Hourihane, Hourihane; Dean, Dean; Warner, Warner

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