Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis

Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of... IntroductionPsoriasis is an immune‐mediated inflammatory disease that affects approximately 1–3% of the population worldwide. An increasing body of evidence supports that the inflammatory process in psoriasis may have systemic consequences with implications for the development of psoriatic comorbidities, including cardiovascular disease (CVD). Psoriasis was suggested to be an independent risk factor for atherosclerosis and CVD.Current concepts favour the idea that inflammation provides a pivotal link between psoriasis and atherosclerosis, which seems to be responsible for the association between the two diseases. Overall, many of the inflammatory products produced in psoriatic skin lesions appear to be released into the systemic circulation as a function of the severity and extent of skin lesions. During periods of active disease, skin‐derived inflammatory products could alter the properties of leucocytes while circulating through the inflamed cutaneous vasculature, or affect endothelial cells at distant sites.The S100 proteins constitute a family of small calcium‐binding proteins that are increasingly recognised as potential players in the pathogenesis of various inflammatory diseases. Several lines of evidence support a crucial role of S100 proteins in the pathogenesis of atherosclerosis, and several S100 molecules have been found to be upregulated in psoriasis, implicating their involvement in its pathogenesis.The antimicrobial S100A proteins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Dermatology Wiley

Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis

Loading next page...
 
/lp/wiley/serum-levels-of-psoriasin-s100a7-and-koebnerisin-s100a15-as-potential-ZfJYSRbNwG
Publisher
Wiley
Copyright
Copyright © 2018 British Association of Dermatologists
ISSN
0307-6938
eISSN
1365-2230
D.O.I.
10.1111/ced.13370
Publisher site
See Article on Publisher Site

Abstract

IntroductionPsoriasis is an immune‐mediated inflammatory disease that affects approximately 1–3% of the population worldwide. An increasing body of evidence supports that the inflammatory process in psoriasis may have systemic consequences with implications for the development of psoriatic comorbidities, including cardiovascular disease (CVD). Psoriasis was suggested to be an independent risk factor for atherosclerosis and CVD.Current concepts favour the idea that inflammation provides a pivotal link between psoriasis and atherosclerosis, which seems to be responsible for the association between the two diseases. Overall, many of the inflammatory products produced in psoriatic skin lesions appear to be released into the systemic circulation as a function of the severity and extent of skin lesions. During periods of active disease, skin‐derived inflammatory products could alter the properties of leucocytes while circulating through the inflamed cutaneous vasculature, or affect endothelial cells at distant sites.The S100 proteins constitute a family of small calcium‐binding proteins that are increasingly recognised as potential players in the pathogenesis of various inflammatory diseases. Several lines of evidence support a crucial role of S100 proteins in the pathogenesis of atherosclerosis, and several S100 molecules have been found to be upregulated in psoriasis, implicating their involvement in its pathogenesis.The antimicrobial S100A proteins

Journal

Clinical & Experimental DermatologyWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off