INTRODUCTIONPolycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive‐aged women worldwide, with a prevalence as high as 15% with the use of the broader Rotterdam criteria. The syndrome is characterized by menstrual irregularity, hyperandrogenism, polycystic ovary morphology and insulin resistance. Insulin resistance is found in most obese women with PCOS and in about 30% of lean patients. Given that most patients with PCOS have a tendency to become insulin resistant, it has been speculated that irisin, a newly discovered myokine, that improves glucose tolerance and alleviates insulin resistance in mice may play a role in the development of PCOS and may also represent a novel PCOS biomarker. Ιrisin can cause energy expenditure and weight loss by converting the stored white adipose tissue to brown adipose tissue and inducing thermogenesis in mice.Current knowledge about the function of the hormone irisin in biological systems is limited. Few studies have examined serum irisin levels in adult women with PCOS; however, data comparing serum irisin concentrations in adult PCOS women with control women have been inconsistent. Four studies demonstrated significantly elevated irisin levels in patients with PCOS compared to those of control women, whereas others showed significantly lower mean serum irisin
Clinical Endocrinology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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