Serum IL‐6 Level and the Development of Disability in Older Persons

Serum IL‐6 Level and the Development of Disability in Older Persons BACKGROUND: The serum concentration of interleukin 6 (IL‐6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age‐associated chronic diseases, which often cause disability, high circulating levels of IL‐6 may contribute to functional decline in old age. We tested the hypothesis that high levels of IL‐6 predict future disability in older persons who are not disabled. METHODS: Participants at the sixth annual follow‐up of the Iowa site of the Established Populations for Epidemiologic Studies of the Elderly aged 71 years or older were considered eligible for this study if they had no disability in regard to mobility or in selected activities of daily living (ADL), and they were re‐interviewed 4 years later. Incident cases of mobility‐disability and of ADL‐disability were identified based on responses at the follow‐up interview. Measures of IL‐6 were obtained from specimens collected at baseline from the 283 participants who developed any disability and from 350 participants selected randomly (46.9%) from those who continued to be non‐disabled. FINDINGS: Participants in the highest IL‐6 tertile were 1.76 (95% CI, 1.17‐2.64) times more likely to develop at least mobility‐disability and 1.62 (95% CI, 1.02‐2.60) times more likely to develop mobility plus ADL‐disability compared with to the lowest IL‐6 tertile. The strength of this association was almost unchanged after adjusting for multiple confounders. The increased risk of mobility‐disability over the full spectrum of IL‐6 concentration was nonlinear, with the risk rising rapidly beyond plasma levels of 2.5 pg/mL. INTERPRETATION: Higher circulating levels of IL‐6 predict disability onset in older persons. This may be attributable to a direct effect of IL‐6 on muscle atrophy and/or to the pathophysiologic role played by IL‐6 in specific diseases. J Am Geriatr Soc 47:639–646, 1999. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

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Publisher
Wiley
Copyright
1999 The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
D.O.I.
10.1111/j.1532-5415.1999.tb01583.x
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND: The serum concentration of interleukin 6 (IL‐6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age‐associated chronic diseases, which often cause disability, high circulating levels of IL‐6 may contribute to functional decline in old age. We tested the hypothesis that high levels of IL‐6 predict future disability in older persons who are not disabled. METHODS: Participants at the sixth annual follow‐up of the Iowa site of the Established Populations for Epidemiologic Studies of the Elderly aged 71 years or older were considered eligible for this study if they had no disability in regard to mobility or in selected activities of daily living (ADL), and they were re‐interviewed 4 years later. Incident cases of mobility‐disability and of ADL‐disability were identified based on responses at the follow‐up interview. Measures of IL‐6 were obtained from specimens collected at baseline from the 283 participants who developed any disability and from 350 participants selected randomly (46.9%) from those who continued to be non‐disabled. FINDINGS: Participants in the highest IL‐6 tertile were 1.76 (95% CI, 1.17‐2.64) times more likely to develop at least mobility‐disability and 1.62 (95% CI, 1.02‐2.60) times more likely to develop mobility plus ADL‐disability compared with to the lowest IL‐6 tertile. The strength of this association was almost unchanged after adjusting for multiple confounders. The increased risk of mobility‐disability over the full spectrum of IL‐6 concentration was nonlinear, with the risk rising rapidly beyond plasma levels of 2.5 pg/mL. INTERPRETATION: Higher circulating levels of IL‐6 predict disability onset in older persons. This may be attributable to a direct effect of IL‐6 on muscle atrophy and/or to the pathophysiologic role played by IL‐6 in specific diseases. J Am Geriatr Soc 47:639–646, 1999.

Journal

Journal of American Geriatrics SocietyWiley

Published: Jun 1, 1999

References

  • Understanding the relationship between disease and disability
    Guralnik, Guralnik
  • Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
    Pacifici, Pacifici
  • Acute‐phase proteins in osteoarthritis
    Sipe, Sipe
  • Indicators of immune activation in major depression
    Sluzwska, Sluzwska; Rybakowski, Rybakowski; Bosmans, Bosmans
  • A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients
    Pfeiffer, Pfeiffer
  • Serum iron level, coronary artery disease, and all‐cause mortality in older men and women
    Corti, Corti; Guralnik, Guralnik; Salive, Salive

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