Serum and CSF immunological findings in ALS

Serum and CSF immunological findings in ALS Serum and CSF immunological findings were analysed in 37 patients with amyotrophic lateral sclerosis (ALS). ALS patients had significantly higher mean values of serum IgG and complement component C4 and significantly lower mean value of total haemolytic titre of complement (THC) compared with normal controls. Incidence of immune complexes (ICs) was significantly higher in sera of ALS patients than in normal controls. There was no significant difference regarding mean serum levels of IgM, IgA, and complement components C3 and Factor B between patients and controls. The blood‐brain barrier (BBB) damage was found in 46% of patients. Intrathecal IgG synthesis was detected in six patients (16%). These results support the hypothesis of immune system involvement in ALS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Scandinavica Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
1991 Blackwell Munksgaard
ISSN
0001-6314
eISSN
1600-0404
D.O.I.
10.1111/j.1600-0404.1991.tb04656.x
Publisher site
See Article on Publisher Site

Abstract

Serum and CSF immunological findings were analysed in 37 patients with amyotrophic lateral sclerosis (ALS). ALS patients had significantly higher mean values of serum IgG and complement component C4 and significantly lower mean value of total haemolytic titre of complement (THC) compared with normal controls. Incidence of immune complexes (ICs) was significantly higher in sera of ALS patients than in normal controls. There was no significant difference regarding mean serum levels of IgM, IgA, and complement components C3 and Factor B between patients and controls. The blood‐brain barrier (BBB) damage was found in 46% of patients. Intrathecal IgG synthesis was detected in six patients (16%). These results support the hypothesis of immune system involvement in ALS.

Journal

Acta Neurologica ScandinavicaWiley

Published: Feb 1, 1991

References

  • Motor Neuron Syndrome and Monoclonal IgM with Antibody Activity Against Gangliosides GM1 and GD1b
    Nardelli, Nardelli; Steck, Steck; Barkas, Barkas; Schluep, Schluep; Jerusalem, Jerusalem
  • Nature and properties of cytotoxic plasma activity in amyotrophic lateral sclerosis
    Ronnevi, Ronnevi; Conradi, Conradi; Karlsson, Karlsson; Sindhupak, Sindhupak

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