ABBREVIATIONSCASCOBAS AmpliScreenICinternal controlCEConformité EuropéeneIDTindividual donation testingLoD(s)limit(s) of detectionMP6minipool of up to 6 donationsMP96minipool of up to 96 donationsMPXv1cobas TaqScreen MPX TestMPXv2cobas TaqScreen MPX Test, version 2.0OBI(s)occult HBV infection(s)RMSRoche Molecular Systems, Inc.RRrepeat reactiveWP(s)window period(s)Multiplex tests for the detection of nucleic acids from hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) are in widespread use for blood and plasma donation screening. These tests supplement serologic testing by detecting early infection before seroconversion, as well as chronic occult HBV infections (OBIs) and have demonstrably improved the safety of the blood supply. Testing is typically accomplished through the use of automated instrumentation, and reagents and instruments are subject to continuous improvement.Current technologies for this testing employ nucleic acid amplification, generally by polymerase chain reaction (PCR) or transcription‐mediated amplification. A relatively recent advance consists of multidye real‐time PCR, which identifies the amplified viral target (HIV, HBV, or HCV) during the primary multiplex screen, eliminating the need for a second round of discriminatory testing.Assays used for testing blood donations require a high level of sensitivity to assure detection of infectious blood units but at the same time must also have high specificity to avoid wastage of safe donations and unnecessary
Transfusion – Wiley
Published: Jan 1, 2018
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