Selection of Compatible Platelet Donors: A Prospective Evaluation of Three Cross‐Matching Techniques

Selection of Compatible Platelet Donors: A Prospective Evaluation of Three Cross‐Matching... A prospective study was undertaken to assess the values of platelet aggregometry, lymphocytotoxicity, and mixed lymphocyte cultures in selecting compatible donors for patients refractory to random platelet transfusions. Donors were selected at random without regard to HLA types. Concurrent with each platelet transfusion, platelet aggregometry and lymphocytotoxicity were performed using patient serum and donor cells. The results were compared with HLA types, MLC, and increments in platelet counts. Forty‐one transfusions were given to 21 patients; 27 were from related and 14 from unrelated donors. Platelet aggregometry was used successfully in selecting compatible donors in 37 cases (90%) with three false negative and one false positive results. Lymphocytotoxicity was useful in 73 per cent of cases with eight false negative and three false positive results. The response to platelet transfusions correlated poorly with HLA matches or MLC reactions. These data suggest platelet aggregometry and lymphocytotoxicity are useful cross‐matching techniques in selection of compatible platelet donors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Selection of Compatible Platelet Donors: A Prospective Evaluation of Three Cross‐Matching Techniques

Transfusion, Volume 17 (6) – Nov 12, 1977

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Publisher
Wiley
Copyright
1977 AABB
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1046/j.1537-2995.1977.17678075665.x
Publisher site
See Article on Publisher Site

Abstract

A prospective study was undertaken to assess the values of platelet aggregometry, lymphocytotoxicity, and mixed lymphocyte cultures in selecting compatible donors for patients refractory to random platelet transfusions. Donors were selected at random without regard to HLA types. Concurrent with each platelet transfusion, platelet aggregometry and lymphocytotoxicity were performed using patient serum and donor cells. The results were compared with HLA types, MLC, and increments in platelet counts. Forty‐one transfusions were given to 21 patients; 27 were from related and 14 from unrelated donors. Platelet aggregometry was used successfully in selecting compatible donors in 37 cases (90%) with three false negative and one false positive results. Lymphocytotoxicity was useful in 73 per cent of cases with eight false negative and three false positive results. The response to platelet transfusions correlated poorly with HLA matches or MLC reactions. These data suggest platelet aggregometry and lymphocytotoxicity are useful cross‐matching techniques in selection of compatible platelet donors.

Journal

TransfusionWiley

Published: Nov 12, 1977

References

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