INTRODUCTIONThe Rh blood group system is one of the most important and complex among the 36 known blood group systems. The RhD antigen is highly immunogenic and has been implicated in transfusion reactions and hemolytic disease of the fetus and newborn. The Rh locus consists of the RHD and the RHCE gene. The high degree of homology and opposite orientation of the two genes favors the production of numerous Rh variants. Broadly Rh variants are classified as weak D, partial D and DEL. RhD variants have been documented to cause allo anti‐D immunization in Rh negative patients after transfusion and pregnancy. RhD variants should be identified as they are clinically important to avoid the risk of immunization. Unlike weak D and partial D antigens which may be identified by routine serology, the DEL variants are not identified by Indirect Antiglobulin Test (IAT) and such individuals are typed as D‐negative. However, reports of primary and secondary immunization of D‐negative recipients by DEL positive units necessitate caution in D negative donors and antenatal women.DEL represents a weakened form of RhD which cannot be detected by conventional serology and requires the use of adsorption elution technique and hence the earlier name Del
Journal of Clinical Laboratory Analysis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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