Screening for DEL phenotype in RhD negative Indians

Screening for DEL phenotype in RhD negative Indians INTRODUCTIONThe Rh blood group system is one of the most important and complex among the 36 known blood group systems. The RhD antigen is highly immunogenic and has been implicated in transfusion reactions and hemolytic disease of the fetus and newborn. The Rh locus consists of the RHD and the RHCE gene. The high degree of homology and opposite orientation of the two genes favors the production of numerous Rh variants. Broadly Rh variants are classified as weak D, partial D and DEL. RhD variants have been documented to cause allo anti‐D immunization in Rh negative patients after transfusion and pregnancy. RhD variants should be identified as they are clinically important to avoid the risk of immunization. Unlike weak D and partial D antigens which may be identified by routine serology, the DEL variants are not identified by Indirect Antiglobulin Test (IAT) and such individuals are typed as D‐negative. However, reports of primary and secondary immunization of D‐negative recipients by DEL positive units necessitate caution in D negative donors and antenatal women.DEL represents a weakened form of RhD which cannot be detected by conventional serology and requires the use of adsorption elution technique and hence the earlier name Del http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22288
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe Rh blood group system is one of the most important and complex among the 36 known blood group systems. The RhD antigen is highly immunogenic and has been implicated in transfusion reactions and hemolytic disease of the fetus and newborn. The Rh locus consists of the RHD and the RHCE gene. The high degree of homology and opposite orientation of the two genes favors the production of numerous Rh variants. Broadly Rh variants are classified as weak D, partial D and DEL. RhD variants have been documented to cause allo anti‐D immunization in Rh negative patients after transfusion and pregnancy. RhD variants should be identified as they are clinically important to avoid the risk of immunization. Unlike weak D and partial D antigens which may be identified by routine serology, the DEL variants are not identified by Indirect Antiglobulin Test (IAT) and such individuals are typed as D‐negative. However, reports of primary and secondary immunization of D‐negative recipients by DEL positive units necessitate caution in D negative donors and antenatal women.DEL represents a weakened form of RhD which cannot be detected by conventional serology and requires the use of adsorption elution technique and hence the earlier name Del

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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