<h1>To the Editor:</h1> Joint hypermobility syndrome (JHS) is a relatively common, but largely unrecognized heritable connective tissue disorder mainly characterized by joint hypermobility (JHM) and related musculoskeletal and non‐musculoskeletal features [Grahame, 2010 ]. A recent consensus statement defines JHS as indistinguishable from the Ehlers–Danlos syndrome hypermobility type (EDS‐HT), which now can be considered one and the same with the former [Tinkle et al., 2009 ]. The associated clinical spectrum of JHS/EDS‐HT is wide and a growing number of studies highlight the overlap with various functional somatic syndromes, including fibromyalgia [Acasuso‐Díaz and Collantes‐Estévez, 1998 ], chronic fatigue syndrome [Castori et al., 2011 ], dysautonomia [Gazit et al., 2003 ], and functional gastrointestinal disorder [Zarate et al., 2010 ]. In particular, unexplained gastrointestinal symptoms, including recurrent abdominal pain, bloating, nausea, reflux, vomiting, constipation, and diarrhea, are found in 35–86% of JHS/EDS‐HT patients [Hakim and Grahame, 2004 ; Castori et al., 2010 ; Zarate et al., 2010 ]. Conversely, JHS and/or generalized JHM are found to be more common among patients suffering from chronic (slow transit) constipation [de Kort et al., 2003 ; Manning et al., 2003 ; Reilly et al., 2008 ], hiatus hernia [Al‐Rawi et al., 2004 ], Crohn's
American Journal of Medical Genetics Part A – Wiley
Published: Sep 1, 2011
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