A77 (P106) Diabetes Remission Clinical Trial (DiRECT): Does hepatic very low density lipoprotein (VLDL) production determine intrapancreatic fat in Type 2 diabetes?A AL‐MRABEH1, SV Zhyzhneuskaya1, C Peters1, AC Barnes2, B Aribisala3, KG Hollingsworth1, H Pilkington4, MEJ Lean5 and R Taylor1Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, 2Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK, 3Computer Science Department, Faculty of Science, Lagos State University, Lagos, Nigeria, 4Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK, 5School of Medicine, Dentistry and Nursing, Royal Infirmary, University of Glasgow, Glasgow, UKAim: VLDL‐triglyceride (VLDL‐TG) supplies fat to all organs. It was hypothesised that following weight loss, the fall in pancreatic fat and improvement in insulin secretion are driven by the decrease in hepatic VLDL production.Methods: The Tyneside cohort of DiRECT (n = 90, age 52.8 ± 0.8 years, body mass index 34.7 ± 0.5 kg/m2, HbA1c 58.8 ± 1.2 mmol/mol) underwent detailed metabolic tests at baseline and after weight loss (825 to 853 kcal/day). Intra‐organ fat was quantified using 3‐point Dixon magnetic resonance imaging, and hepatic very low density lipoprotein 1 (VLDL1‐TG) production was measured using a competitive blocking non‐isotopic method. Insulin secretion was measured by
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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