Scanning Electron Microscope Studies of Red Cell Morphology

Scanning Electron Microscope Studies of Red Cell Morphology Abstract. Observations were made of changes in red cell morphology in blood stored in acid citrate dextrose over a period of six weeks using the scanning electron microscope. It was found possible to demonstrate the various stages of red cell transformation from biconcave discs, through a crenated stage to the final spheroidal state. Adenine was shown to slow down these changes. It is postulated that the red cell membrane changes are reversible up to the stage of the crenated spheroid cell, but subsequent changes result in a rapid destruction of the cell if transfused. The scanning electron microscopy studies can, therefore, be a useful method of observing the effect on red cell shape of new anticoagulants, red cell storage procedures and biochemical changes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vox Sanguinis Wiley

Scanning Electron Microscope Studies of Red Cell Morphology

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Publisher
Wiley
Copyright
© 1972 Blackwell Publishing Ltd
ISSN
0042-9007
eISSN
1423-0410
D.O.I.
10.1111/j.1423-0410.1972.tb05122.x
Publisher site
See Article on Publisher Site

Abstract

Abstract. Observations were made of changes in red cell morphology in blood stored in acid citrate dextrose over a period of six weeks using the scanning electron microscope. It was found possible to demonstrate the various stages of red cell transformation from biconcave discs, through a crenated stage to the final spheroidal state. Adenine was shown to slow down these changes. It is postulated that the red cell membrane changes are reversible up to the stage of the crenated spheroid cell, but subsequent changes result in a rapid destruction of the cell if transfused. The scanning electron microscopy studies can, therefore, be a useful method of observing the effect on red cell shape of new anticoagulants, red cell storage procedures and biochemical changes.

Journal

Vox SanguinisWiley

Published: Feb 1, 1972

References

  • Further studies on the effect of adenine in blood preservation
    Akerblom, Akerblom; Verdier, Verdier; Finnson, Finnson; Garby, Garby; Hogman, Hogman; Johansson, Johansson
  • Comparison studies of whole blood stored in ACD and CPD and with adenine
    Shields, Shields

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