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Y. Li, Z. Li (2000)
[Mitochondria and apoptosis].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 34 3
K. Abe, M. Aoki, J. Kawagoe, Toshimichi Yoshida, A. Hattori, K. Kogure, Y. Itoyama (1995)
Ischemic delayed neuronal death. A mitochondrial hypothesis.Stroke, 26 8
L. Schwartz, Sallie Smith, Margaret Jones, B. Osborne (1993)
Do all programmed cell deaths occur via apoptosis?Proceedings of the National Academy of Sciences of the United States of America, 90
M. Ginsberg, W. Pulsinelli (1994)
The ischemic penumbra, injury thresholds, and the therapeutic window for acute strokeAnnals of Neurology, 36
G. Zoppo, G. Schmid-Schönbein, E. Mori, B. Copeland, Cheng‐Ming Chang (1991)
Polymorphonuclear Leukocytes Occlude Capillaries Following Middle Cerebral Artery Occlusion and Reperfusion in BaboonsStroke, 22
K. Abe (2000)
Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain InjuryJournal of Cerebral Blood Flow & Metabolism, 20
D. Kang, J. Roh, Yongseok Lee, I. Song, Byung-Woo Yoon, K. Chang (2000)
Neuronal metabolic changes in the cortical region after subcortical infarction: a proton MR spectroscopy studyJournal of Neurology, Neurosurgery & Psychiatry, 69
Fuhai Li, Sam Han, T. Tatlisumak, Kaiyin Liu, Julio Garcia, C. Sotak, M. Fisher (1999)
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in ratsAnnals of Neurology, 46
H. Xiang, Y. Kinoshita, C. Knudson, S. Korsmeyer, P. Schwartzkroin, R. Morrison, R. Morrison (1998)
Bax Involvement in p53-Mediated Neuronal Cell DeathThe Journal of Neuroscience, 18
Jun Chen, T. Nagayama, K. Jin, R. Stetler, Raymond Zhu, S. Graham, R. Simon (1998)
Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral IschemiaThe Journal of Neuroscience, 18
B. Kraupp, B. Ruttkay-Nedecky, Helga Koudelka, Krystyna Bukowska, W. Bursch, R. Schulte‐Hermann (1995)
In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary noteHepatology, 21
S. Schneweis (2000)
Intra-arterial Prourokinase for Acute Ischemic StrokeJAMA, 283
G. Mies, Takehiko lijima, Konstantin-Alexander Hossmann (1993)
Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat.Neuroreport, 4 6
(1999)
Limiting neurological damage after stroke. A review of pharmacological treatment options
S. Kriegler, S. Chiu (1993)
Calcium signaling of glial cells along mammalian axons, 13
J. Macmanus, H. Fliss, E. Preston, I. Rasquinha, U. Tuor (1999)
Cerebral Ischemia Produces Laddered DNA Fragments Distinct from Cardiac Ischemia and Archetypal ApoptosisJournal of Cerebral Blood Flow & Metabolism, 19
F. Colbourne, G. Sutherland, R. Auer (1999)
Electron Microscopic Evidence against Apoptosis as the Mechanism of Neuronal Death in Global IschemiaThe Journal of Neuroscience, 19
T. Jones, R. Morawetz, R. Crowell, F. Marcoux, S. Fitzgibbon, U. Degirolami, R. Ojemann (1981)
Thresholds of focal cerebral ischemia in awake monkeys.Journal of neurosurgery, 54 6
M. Cotrina, Jian Kang, J. Lin, E. Bueno, T. Hansen, L. He, Yulin Liu, M. Nedergaard (1998)
Astrocytic Gap Junctions Remain Open during Ischemic ConditionsThe Journal of Neuroscience, 18
F. Colbourne, Hui Li, A. Buchan, J. Clemens (1999)
Continuing postischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats.Stroke, 30 3
P. Stys (1998)
Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to TherapeuticsJournal of Cerebral Blood Flow & Metabolism, 18
R. Gold, M. Schmied, G. Giegerich, H. Breitschopf, H. Hartung, K. Toyka, H. Lassmann (1994)
Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.Laboratory investigation; a journal of technical methods and pathology, 71 2
S. Namura, Jinmin Zhu, K. Fink, M. Endres, A. Srinivasan, K. Tomaselli, Junying Yuan, M. Moskowitz (1998)
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral IschemiaThe Journal of Neuroscience, 18
P. Barber, Fracp, Stephen Davis, B. Infeld, Alison Baird, G. Donnan, Damien Jolley, Meir Lichtenstein (1998)
Spontaneous reperfusion after ischemic stroke is associated with improved outcome.Stroke, 29 12
M. Nedergaard, J. Astrup (1986)
Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [14C]2-Deoxyglucose PhosphorylationJournal of Cerebral Blood Flow & Metabolism, 6
R. Wender, A. Brown, R. Fern, R. Swanson, Kevin Farrell, B. Ransom (2000)
Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White MatterThe Journal of Neuroscience, 20
L. Pantoni, Julio Garcia, J. Gutierrez (1996)
Cerebral white matter is highly vulnerable to ischemia.Stroke, 27 9
C. Petito, J. Torres-Muñoz, B. Roberts, John-Paul Olarte, T. Nowak, W. Pulsinelli (1997)
DNA Fragmentation Follows Delayed Neuronal Death in CA1 Neurons Exposed to Transient Global Ischemia in the RatJournal of Cerebral Blood Flow & Metabolism, 17
H. Hara, R. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Zhihong Huang, M. Shimizu‐Sasamata, Junying Yuan, M. Moskowitz (1997)
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.Proceedings of the National Academy of Sciences of the United States of America, 94 5
A. Green, A. Hainsworth, D. Jackson (2000)
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic strokeNeuropharmacology, 39
G. Mies, K. Kohno, K. Hossmann (1994)
Prevention of Periinfarct Direct Current Shifts with Glutamate Antagonist NBQX following Occlusion of the Middle Cerebral Artery in the RatJournal of Cerebral Blood Flow & Metabolism, 14
J. Mcdonald, S. Althomsons, K. Hyrc, D. Choi, M. Goldberg (1998)
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicityNature Medicine, 4
(2000)
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
Julio Garcia, N. Lassen, C. Weiller, B. Sperling, J. Nakagawara (1996)
Ischemic stroke and incomplete infarction.Stroke, 27 4
G. Mies, L. Auer, G. Ebhardt, H. Traupe, W. Heiss (1983)
Flow and neuronal density in tissue surrounding chronic infarction.Stroke, 14
A. Furlan, R. Higashida, L. Wechsler, M. Gent, H. Rowley, C. Kase, M. Pessin, A. Ahuja, F. Callahan, W. Clark, F. Silver, F. Rivera (1999)
Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled TrialJAMA, 282
W. Heiss, R. Graf, J. Löttgen, K. Ohta, T. Fujita, R. Wagner, M. Grond, K. Weinhard (1997)
Repeat Positron Emission Tomographic Studies in Transient Middle Cerebral Artery Occlusion in Cats: Residual Perfusion and Efficacy of Postischemic ReperfusionJournal of Cerebral Blood Flow & Metabolism, 17
F. Sharp, A. Lu, Yang Tang, D. Millhorn (2000)
Multiple Molecular Penumbras after Focal Cerebral IschemiaJournal of Cerebral Blood Flow & Metabolism, 20
W. Heiss (2000)
Ischemic Penumbra: Evidence From Functional Imaging in ManJournal of Cerebral Blood Flow & Metabolism, 20
T. Neumann-Haefelin, A. Kastrup, A. Crespigny, M. Yenari, T. Ringer, Guo-hua Sun, M. Moseley, M. Fisher (2000)
Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation.Stroke, 31 8
Huaidong Wang, T. Fukuda, Tomoko Suzuki, K. Hashimoto, S. Liou, T. Momoi, T. Kosaka, K. Yamamoto, H. Nakanishi (1999)
Differential effects of Bcl‐2 overexpression on hippocampal CA1 neurons and dentate granule cells following hypoxic ischemia in adult miceJournal of Neuroscience Research, 57
N. Lassen (1982)
Incomplete cerebral infarction‐‐focal incomplete ischemic tissue necrosis not leading to emollision.Stroke, 13
Stroke Roundtable (1999)
Recommendations for standards regarding preclinical neuroprotective and restorative drug development.Stroke, 30 12
G. Marchal, A. Young, J. Baron (1999)
Early Postischemic Hyperperfusion: Pathophysiologic Insights from Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 19
S. Muchmore, M. Sattler, H. Liang, R. Meadows, J. Harlan, H. Yoon, D. Nettesheim, Brian Chang, C. Thompson, Sui‐Lam Wong, S. Ng, S. Fesik (1996)
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell deathNature, 381
J. Gillard, P. Barker, P. Barker, P. Zijl, R. Bryan, S. Oppenheimer (1996)
Proton MR spectroscopy in acute middle cerebral artery stroke.AJNR. American journal of neuroradiology, 17 5
B. Johansson (2000)
Brain plasticity and stroke rehabilitation. The Willis lecture.Stroke, 31 1
T. Abumiya, R. Fitridge, C. Mazur, B. Copeland, J. Koziol, J. Tschopp, M. Pierschbacher, G. Zoppo (2000)
Integrin αIIbβ3 Inhibitor Preserves Microvascular Patency in Experimental Acute Focal Cerebral IschemiaStroke, 31
Nancy Thornberry, Y. Lazebnik (1998)
Caspases: enemies within.Science, 281 5381
J. Grotta, M. Kothari, K. Welch, J. Broderick, B. Tilley, T. Brott, Marler, P. Lyden, P. O'Byrne (1995)
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.The New England Journal of Medicine
W. Powers, R. Grubb, D. Darriet, M. Raichle (1985)
Cerebral Blood Flow and Cerebral Metabolic Rate of Oxygen Requirements for Cerebral Function and Viability in HumansJournal of Cerebral Blood Flow & Metabolism, 5
Koroshetz Wj (1996)
Tissue plasminogen activator for acute ischemic stroke.The New England journal of medicine, 333 24
R.M LoPachin, P. Stys (1995)
Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation, 15
T. Abumiya, R. Fitridge, C. Mazur, B. Copeland, J. Koziol, J. Tschopp, M. Pierschbacher, G. Zoppo (2000)
Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia.Stroke, 31 6
M. Gyngell, T. Back, Mathias Hoehn-Berlage, K. Kohno, K. Hossmann (1994)
Transient cell depolarization after permanent middle cerebral artery occlusion: An observation by diffusion‐weighted MRI and localized 1H‐MRSMagnetic Resonance in Medicine, 31
J. Astrup, L. Symon, N. Branston, N. Lassen (1977)
Cortical Evoked Potential and Extracellular K+ and H+ at Critical Levels of Brain IschemiaStroke, 8
C. Weiller, K. Willmes, W. Reiche, A. Thron, C. Isensee, U. Buell, E. Ringelstein (1993)
The case of aphasia or neglect after striatocapsular infarction.Brain : a journal of neurology, 116 ( Pt 6)
G. Mies, S. Ishimaru, Y. Xie, K. Seo, K. Hossmann (1991)
Ischemic Thresholds of Cerebral Protein Synthesis and Energy State following Middle Cerebral Artery Occlusion in RatJournal of Cerebral Blood Flow & Metabolism, 11
A. Sorensen, W. Copen, L. Østergaard, F. Buonanno, R. Gonzalez, G. Rordorf, B. Rosen, L. Schwamm, R. Weisskoff, Walter Koroshetz (1999)
Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.Radiology, 210 2
Yi Li, M. Chopp, N. Jiang, Zhenggang Zhang, C. Zaloga (1995)
Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats.Stroke, 26 7
J. Lee, G. Zipfel, D. Choi (1999)
The changing landscape of ischaemic brain injury mechanismsNature, 399
Julio Garcia, Kaiyin Liu, Z. Ye, J. Gutierrez (1997)
Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats.Stroke, 28 11
E. Mori, G. Zoppo, J. Chambers, B. Copeland, K. Arfors (1992)
Inhibition of Polymorphonuclear Leukocyte Adherence Suppresses No‐Reflow After Focal Cerebral Ischemia in BaboonsStroke, 23
U. Degirolami, R. Crowell, F. Marcoux (1984)
Selective Necrosis and Total Necrosis in Focal Cerebral ischemia. Neuropathologic Observations on Experimental Middle Cerebral Artery Occlusion in the Macaque MonkeyJournal of Neuropathology and Experimental Neurology, 43
Carrie Markgraf, Nelson Velayo, Michael Johnson, Deborah McCarty, Shujaath Medhi, Jack Koehl, Paula Chmielewski, Matthew Linnik (1998)
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.Stroke, 29 1
Raymond Swanson, Stephen Sagar, Frank Sharp (1989)
Regional brain glycogen stores and metabolism during complete global ischaemia.Neurological research, 11 1
C. Du, R. Hu, C. Csernansky, C. Hsu, D. Choi (1996)
Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?Journal of Cerebral Blood Flow & Metabolism, 16
A. Baird, G. Donnan, M. Austin, W. Mckay (1995)
Early reperfusion in the ‘spectacular shrinking deficit’ demonstrated by single‐photon emission computed tomographyNeurology, 45
P. Lapchak, D. Chapman, J. Zivin (2001)
Pharmacological Effects of the Spin Trap Agents N-t-Butyl-Phenylnitrone (PBN) and 2,2,6,6-Tetramethylpiperidine-N-Oxyl (TEMPO) in a Rabbit Thromboembolic Stroke Model: Combination Studies With the Thrombolytic Tissue Plasminogen ActivatorStroke: Journal of the American Heart Association, 32
C. Kidwell, J. Saver, J. Mattiello, S. Starkman, F. Viñuela, G. Duckwiler, Y. Gobin, R. Jahan, P. Vespa, M. Kalafut, J. Alger (2000)
Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imagingAnnals of Neurology, 47
D. Saunders, F. Howe, A. Boogaart, M. McLean, J. Griffiths, Martin Brown (1995)
Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy.Stroke, 26 6
S. Read, T. Hirano, D. Abbott, R. Markus, J. Sachinidis, Henri Tochon-Danguy, J. Chan, G. Egan, Andrew Scott, C. Bladin, W. McKay, Geoffrey Donnan (2000)
The fate of hypoxic tissue on 18F‐fluoromisonidazole positron emission tomography after ischemic strokeAnnals of Neurology, 48
D. Sherman, R. Atkinson, T. Chippendale, K. Levin, Ken Ng, N. Futrell, C-Y Hsu, D. Levy (2000)
Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke Treatment with Ancrod Trial.JAMA, 283 18
B. Wolf, J. Goldstein, H. Stennicke, H. Beere, G. Amarante-Mendes, G. Salvesen, D. Green (1999)
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation
A. Baird, S. Warach
Journal of Cerebral Blood Flow and Metabolism Magnetic Resonance Imaging of Acute Stroke
1. The ischaemic penumbra is defined as a moderately hypoperfused region that retains structural integrity but has lost function. In animal models of ischaemic stroke, this region is prone to recurrent anoxic depolarization and will become infarcted if reperfusion does not occur. In the macaque model, an ischaemic penumbra has been identified for up to 3 h after ischaemic stroke onset, whereas in selected human patients it may exist for up to 48 h.
Clinical and Experimental Pharmacology and Physiology – Wiley
Published: Feb 14, 2003
Keywords: ; ; ; ; ; ; ; ;
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