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Salvaging The Ischaemic Penumbra: More Than Just Reperfusion?

Salvaging The Ischaemic Penumbra: More Than Just Reperfusion? 1. The ischaemic penumbra is defined as a moderately hypoperfused region that retains structural integrity but has lost function. In animal models of ischaemic stroke, this region is prone to recurrent anoxic depolarization and will become infarcted if reperfusion does not occur. In the macaque model, an ischaemic penumbra has been identified for up to 3 h after ischaemic stroke onset, whereas in selected human patients it may exist for up to 48 h. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Pharmacology and Physiology Wiley

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References (75)

Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0305-1870
eISSN
1440-1681
DOI
10.1046/j.1440-1681.2002.03609.x
Publisher site
See Article on Publisher Site

Abstract

1. The ischaemic penumbra is defined as a moderately hypoperfused region that retains structural integrity but has lost function. In animal models of ischaemic stroke, this region is prone to recurrent anoxic depolarization and will become infarcted if reperfusion does not occur. In the macaque model, an ischaemic penumbra has been identified for up to 3 h after ischaemic stroke onset, whereas in selected human patients it may exist for up to 48 h.

Journal

Clinical and Experimental Pharmacology and PhysiologyWiley

Published: Feb 14, 2003

Keywords: ; ; ; ; ; ; ; ;

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