In a recent study published in the Proceedings of the National Academy of Sciences of the USA, Jau‐Song Yu et al () reported of their generated four‐protein biomarker panel consisting of MMP1, KNG1, ANXA2, and HSPA5, as based on a risk score scheme they established. This panel showed high sensitivity (87.5%) and specificity (80.5%) values in a test set to distinguish OSCC patients' saliva samples from non‐OSCC patients' saliva samples. The risk score >0.4 detected 84% of the stage I OSCCs and a significant portion (42%) of the high‐risk, visible, oral potentially malignant disorders (OPMDs). Moreover, among 88 high‐risk OPMD patients with available follow‐up results, 18 developed OSCC within 5 years; of these, nearly 78% had risk scores >0.4. The authors concluded that their four‐protein panel may therefore offer a clinically effective tool for detecting OSCC and monitoring high‐risk OPMDs through a readily available biofluid (i.e., saliva).In this study, Yu et al () used the modern liquid chromatography–tandem mass spectrometry (LC‐MS/MS) with multiple reaction monitoring (MRM) mode (LC‐MRM‐MS) assay in order to detect these four biomarkers in salivary samples of 96 healthy controls, 103 low‐risk OPMD, 130 high‐risk OPMD, and 131 OSCC patients. The LC‐MRM‐MS mode assay is a very powerful tool
Oral Diseases – Wiley
Published: Jan 1, 2018
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