Safe‐by‐Design Ligand‐Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells

Safe‐by‐Design Ligand‐Coated ZnO Nanocrystals Engineered by an Organometallic Approach:... The unique physicochemical properties and biocompatibility of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on the nanocrystal/ligand interface, which is largely determined by synthetic procedures. Stable ZnO NCs coated with a densely packed shell of 2‐(2‐methoxyethoxy)acetate ligands, which act as miniPEG prototypes, with average core size and hydrodynamic diameter of 4–5 and about 12 nm, respectively, were prepared by an organometallic self‐supporting approach, fully characterized, and used as a model system for biological studies. The ZnO NCs from the one‐pot, self‐supporting organometallic procedure exhibit unique physicochemical properties such as relatively high quantum yield (up to 28 %), ultralong photoluminescence decay (up to 2.1 μs), and EPR silence under standard conditions. The cytotoxicity of the resulting ZnO NCs toward normal (MRC‐5) and cancer (A549) human lung cell lines was tested by MTT assay, which demonstrated that these brightly luminescent, quantum‐sized ZnO NCs have a low negative impact on mammalian cell lines. These results substantiate that the self‐supporting organometallic approach is a highly promising method to obtain high‐quality, nontoxic, ligand‐coated ZnO NCs with prospective biomedical applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry - A European Journal Wiley

Safe‐by‐Design Ligand‐Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells

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Publisher
Wiley
Copyright
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
0947-6539
eISSN
1521-3765
D.O.I.
10.1002/chem.201704207
Publisher site
See Article on Publisher Site

Abstract

The unique physicochemical properties and biocompatibility of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on the nanocrystal/ligand interface, which is largely determined by synthetic procedures. Stable ZnO NCs coated with a densely packed shell of 2‐(2‐methoxyethoxy)acetate ligands, which act as miniPEG prototypes, with average core size and hydrodynamic diameter of 4–5 and about 12 nm, respectively, were prepared by an organometallic self‐supporting approach, fully characterized, and used as a model system for biological studies. The ZnO NCs from the one‐pot, self‐supporting organometallic procedure exhibit unique physicochemical properties such as relatively high quantum yield (up to 28 %), ultralong photoluminescence decay (up to 2.1 μs), and EPR silence under standard conditions. The cytotoxicity of the resulting ZnO NCs toward normal (MRC‐5) and cancer (A549) human lung cell lines was tested by MTT assay, which demonstrated that these brightly luminescent, quantum‐sized ZnO NCs have a low negative impact on mammalian cell lines. These results substantiate that the self‐supporting organometallic approach is a highly promising method to obtain high‐quality, nontoxic, ligand‐coated ZnO NCs with prospective biomedical applications.

Journal

Chemistry - A European JournalWiley

Published: Jan 15, 2018

Keywords: ; ; ; ;

References

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