Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different Rat Strains

Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different... Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn‐Hooded (FH), alcohol‐preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol‐nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r =+0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross‐breeding the ethanol‐preferring FH rats with the ethanol‐nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism: Clinical & Experimental Research Wiley

Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different Rat Strains

Loading next page...
 
/lp/wiley/saccharin-intake-predicts-ethanol-intake-in-genetically-heterogeneous-0mBcZWfNQw
Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0145-6008
eISSN
1530-0277
DOI
10.1111/j.1530-0277.1993.tb00777.x
Publisher site
See Article on Publisher Site

Abstract

Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn‐Hooded (FH), alcohol‐preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol‐nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r =+0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross‐breeding the ethanol‐preferring FH rats with the ethanol‐nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis.

Journal

Alcoholism: Clinical & Experimental ResearchWiley

Published: Apr 1, 1993

Keywords: ; ; ;

References

  • Single‐locus control of saccharine intake in BXD/Ty recombinant inbred (RI) mice: Some methodological implications for RI strain Analysis
    Belknap, JK; Crabbe, JD; Plomin, R
  • Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats
    McBride, WJ; Murphy, JM; Lumeng, L; Li, TK

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off