RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis

RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early... INTRODUCTIONBronchiolitis is the most common cause of lower respiratory infection in the first year of life. Although most children with bronchiolitis have mild disease and are managed at home, infants admitted to hospital for the condition almost always have severe symptoms. The clinical relevance of the identification of the specific pathogens or combination of pathogens infecting a child remains unclear. However, children with human rhinovirus (hRV) may have different short‐ and long‐term outcomes compared to children with respiratory syncytial virus (RSV). We showed that clinical severity was not correlated with the level of serum Krebs von den Lungen 6 antigen (KL‐6), a biomarker of epithelial dysfunction, in previously healthy children, which indicates that the various clinical outcomes depend more on the adaptive capacities of the host rather than the intensity of epithelial dysfunction. Prediction of the risk of recurrent wheezing or long‐term asthma from the first year of life can be challenging. Against this background, we decided to prospectively follow a cohort of infants with an early episode of acute bronchiolitis, either hospitalized or cared for at home. Our main objective was to assess the risk factors for developing symptoms of recurrent bronchial obstruction during a 3‐year follow‐up after http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25037
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONBronchiolitis is the most common cause of lower respiratory infection in the first year of life. Although most children with bronchiolitis have mild disease and are managed at home, infants admitted to hospital for the condition almost always have severe symptoms. The clinical relevance of the identification of the specific pathogens or combination of pathogens infecting a child remains unclear. However, children with human rhinovirus (hRV) may have different short‐ and long‐term outcomes compared to children with respiratory syncytial virus (RSV). We showed that clinical severity was not correlated with the level of serum Krebs von den Lungen 6 antigen (KL‐6), a biomarker of epithelial dysfunction, in previously healthy children, which indicates that the various clinical outcomes depend more on the adaptive capacities of the host rather than the intensity of epithelial dysfunction. Prediction of the risk of recurrent wheezing or long‐term asthma from the first year of life can be challenging. Against this background, we decided to prospectively follow a cohort of infants with an early episode of acute bronchiolitis, either hospitalized or cared for at home. Our main objective was to assess the risk factors for developing symptoms of recurrent bronchial obstruction during a 3‐year follow‐up after

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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