Role of the paraventricular nucleus microenvironment in stress integration *

Role of the paraventricular nucleus microenvironment in stress integration * The hypothalamic paraventricular nucleus is the primary controller of hypothalamo‐pituitary–adrenocortical glucocorticoid release. In performing this function, the paraventricular nucleus summates a variety of information from both external and internal sources into a net secretory signal to the adrenal cortex. In this review, we will provide an overview of neuronal circuit mechanisms governing activation and inhibition of hypophysiotrophic neurons, highlight recent developments in our understanding of nonsynaptic mechanisms regulating paraventricular cellular activity, including dendritic neuropeptide release, direct steroid feedback, cytokine cascades and gaseous neurotransmission, and illustrate the capacity for hypophysiotrophic, neurohypophysial and preautonomic paraventricular effector pathways to work together in control of glucocorticoid release. The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Role of the paraventricular nucleus microenvironment in stress integration *

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1046/j.1460-9568.2002.02133.x
Publisher site
See Article on Publisher Site

Abstract

The hypothalamic paraventricular nucleus is the primary controller of hypothalamo‐pituitary–adrenocortical glucocorticoid release. In performing this function, the paraventricular nucleus summates a variety of information from both external and internal sources into a net secretory signal to the adrenal cortex. In this review, we will provide an overview of neuronal circuit mechanisms governing activation and inhibition of hypophysiotrophic neurons, highlight recent developments in our understanding of nonsynaptic mechanisms regulating paraventricular cellular activity, including dendritic neuropeptide release, direct steroid feedback, cytokine cascades and gaseous neurotransmission, and illustrate the capacity for hypophysiotrophic, neurohypophysial and preautonomic paraventricular effector pathways to work together in control of glucocorticoid release. The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation.

Journal

European Journal of NeuroscienceWiley

Published: Aug 1, 2002

References

  • Expression of ionotropic glutamate receptor subunit mRNAs by paraventricular corticotropin‐releasing factor (CRF) neurons
    Aubry, Aubry; Bartanusz, Bartanusz; Pagliusi, Pagliusi; Schulz, Schulz; Kiss, Kiss
  • Splanchnicotomy increases adrenal sensitivity to ACTH in nonstressed rats
    Jasper, Jasper; Engeland, Engeland
  • Dendritic release of vasopressin and oxytocin
    Ludwig, Ludwig
  • Connections of the rat lateral septal complex
    Risold, Risold; Swanson, Swanson
  • Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
    Swanson, Swanson; Sawchenko, Sawchenko
  • Demonstration of glucocorticoid receptor‐like immunoreactivity in glucocorticoid‐sensitive vasopressin and corticotropin‐releasing factor neurons in the hypothalamic paraventricular nucleus
    Uht, Uht; McKelvy, McKelvy; Harrison, Harrison; Bohn, Bohn
  • Excitatory amino acid antagonists inhibit synaptic responses in the guinea pig hypothalamic paraventricular nucleus
    Wuarin, Wuarin; Dudek, Dudek

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