Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking

María Pascual; Jorge Montesinos; Consuelo Guerri

doi:10.1002/jnr.24203

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Publisher: Wiley Subscription Services, Inc., A Wiley Company
Copyright: © 2018 Wiley Periodicals, Inc.
ISSN: 0360-4012
eISSN: 1097-4547
D.O.I.: 10.1002/jnr.24203
Publisher site: See Article on Publisher Site

Abstract

Adolescence is a critical stage of brain maturation in which important plastic and dynamic processes take place in different brain regions, leading to development of the adult brain. Ethanol drinking in adolescence disrupts brain plasticity and causes structural and functional changes in immature brain areas (prefrontal cortex, limbic system) that result in cognitive and behavioral deficits. These changes, along with secretion of sexual and stress‐related hormones in adolescence, may impact self‐control, decision making, and risk‐taking behaviors that contribute to anxiety and initiation of alcohol consumption. New data support the participation of the neuroimmune system in the effects of ethanol on the developing and adult brain. This article reviews the potential pathological bases that underlie the effects of alcohol on the adolescent brain, such as the contribution of genetic background, the perturbation of epigenetic programming, and the influence of the neuroimmune response. Special emphasis is given to the actions of ethanol in the innate immune receptor toll‐like receptor 4 (TLR4), since recent studies have demonstrated that by activating the inflammatory TLR4/NFκB signaling response in glial cells, binge drinking of ethanol triggers the release of cytokines/chemokines and free radicals, which exacerbate the immune response that causes neuroinflammation/neural damage as well as short‐ and long‐term neurophysiological, cognitive, and behavioral dysfunction. Finally, potential treatments that target the neuroimmune response to treat the neuropathological and behavioral consequences of adolescent alcohol abuse are discussed.

Journal

Journal of Neuroscience Research – Wiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

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Steinberg, L.; Icenogle, G.; Shulman, E. P.; Breiner, K.; Chein, J.; Bacchini, D.; Takash, H. M.
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Stellwagen, D.; Beattie, E. C.; Seo, J. Y.; Malenka, R. C.
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Stevens, B.; Allen, N. J.; Vazquez, L. E.; Howell, G. R.; Christopherson, K. S.; Nouri, N.; Barres, B. A.
Activation of nuclear PPARgamma receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking

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"Binge" drinking experience in adolescent mice shows sex differences and elevated ethanol intake in adulthood

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Swartzwelder, H. S.; Wilson, W. A.; Tayyeb, M. I.
Alcohol's effect on host defense

Szabo, G.; Saha, B.
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Szumlinski, K. K.; Diab, M. E.; Friedman, R.; Henze, L. M.; Lominac, K. D.; Bowers, M. S.
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Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking

Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking

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Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking

Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking

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