IntroductionSkin cancer patients are known to be at increased risk of developing subsequent skin cancers due to shared risk factors: large parts of their skin have usually been exposed to mutagenic changes as a result of exposure to UV radiation or other carcinogens. This so‐called field cancerization in combination with the generally good prognosis of adequately treated skin cancer gives ample opportunity for new skin cancers to develop. Other shared risk factors like genetics and immune suppression might further increase the occurrence of subsequent skin cancers.Two meta‐analyses reported pooled risks for a subsequent melanoma or keratinocyte carcinoma (KC, including squamous cell carcinoma [SCC] and basal cell carcinoma, [BCC]) in melanoma and KC patients. A previous melanoma was shown to be a strong predictor for development of a subsequent melanoma (pooled standardized incidence ratio [SIR]: 10.4) and to a lesser extent of a subsequent KC: SIR 2.8–4.6. A prior KC is a very strong predictor of a subsequent KC, with a mean 5‐year cumulative risk 36.2% and to a less extent melanoma (pooled proportion 0.5%). The majority of previous studies, included in the meta‐analyses or published thereafter, only reported proportions of patients developing subsequent skin cancers. Proportions are quite an
Journal of the European Academy of Dermatology & Venereology – Wiley
Published: Jan 1, 2018
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