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Ribonucleases P/MRP and the Expanding Ribonucleoprotein World

Ribonucleases P/MRP and the Expanding Ribonucleoprotein World One of the hallmarks of life is the widespread use of certain essential ribozymes. The ubiquitous ribonuclease P (RNase P) and eukaryotic RNase MRP are essential complexes where a structured, noncoding RNA acts in catalysis. Recent discoveries have elucidated the three‐dimensional structure of the ancestral ribonucleoprotein complex, suggested the possibility of a protein‐only composition in organelles, and even noted the absence of RNase P in a non‐free‐living organism. With respect to these last two findings, import mechanisms for RNases P/MRP into mitochondria have been demonstrated, and RNase P is present in organisms with some of the smallest known genomes. Together, these results have led to an ongoing debate regarding the precise definition of how “essential” these ribozymes truly are. © IUBMB IUBMB Life, 2012. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

Ribonucleases P/MRP and the Expanding Ribonucleoprotein World

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References (108)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1002/iub.1052
pmid
22605678
Publisher site
See Article on Publisher Site

Abstract

One of the hallmarks of life is the widespread use of certain essential ribozymes. The ubiquitous ribonuclease P (RNase P) and eukaryotic RNase MRP are essential complexes where a structured, noncoding RNA acts in catalysis. Recent discoveries have elucidated the three‐dimensional structure of the ancestral ribonucleoprotein complex, suggested the possibility of a protein‐only composition in organelles, and even noted the absence of RNase P in a non‐free‐living organism. With respect to these last two findings, import mechanisms for RNases P/MRP into mitochondria have been demonstrated, and RNase P is present in organisms with some of the smallest known genomes. Together, these results have led to an ongoing debate regarding the precise definition of how “essential” these ribozymes truly are. © IUBMB IUBMB Life, 2012.

Journal

IUBMB LifeWiley

Published: Jun 1, 2012

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