Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats

Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death... Twenty‐two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral artery occlusion (n = 5 per group) or sham occlusion (n = 2) in the magnetic resonance imaging unit. Diffusion‐, perfusion‐, and T2‐weighted imaging were acquired before and during occlusion, and after reperfusion. A coregistration method was used to correlate the acute changes of the average apparent diffusion coefficient (ADCav) with the histology after 72 hours at the same topographic sites. The initially reduced ADCav values recovered completely in both the lateral caudoputamen and upper frontoparietal cortex in the 8‐, 15‐, and 30‐minute groups, partially in the cortex, and not at all in the caudoputamen in the 60‐minute group. The histology showed that the caudoputamen was either normal or had mild neuronal injury in the 8‐minute group and invariably had some degree of neuronal death in the 15‐, 30‐, and 60‐minute groups, whereas the cortex was either normal or had varying degrees of neuronal injury in all groups. No histological abnormalities were seen in the sham‐operated rats. Our data suggest that acute ADCav reversal does not always predict tissue recovery from ischemic injury and that temporary focal ischemia for even 8‐minute duration can cause delayed neuronal death that is more severe in the caudoputamen where the initial ADCav decline was greater than in the cortex. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats

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Publisher
Wiley
Copyright
Copyright © 1999 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
D.O.I.
10.1002/1531-8249(199909)46:3<333::AID-ANA9>3.0.CO;2-X
Publisher site
See Article on Publisher Site

Abstract

Twenty‐two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral artery occlusion (n = 5 per group) or sham occlusion (n = 2) in the magnetic resonance imaging unit. Diffusion‐, perfusion‐, and T2‐weighted imaging were acquired before and during occlusion, and after reperfusion. A coregistration method was used to correlate the acute changes of the average apparent diffusion coefficient (ADCav) with the histology after 72 hours at the same topographic sites. The initially reduced ADCav values recovered completely in both the lateral caudoputamen and upper frontoparietal cortex in the 8‐, 15‐, and 30‐minute groups, partially in the cortex, and not at all in the caudoputamen in the 60‐minute group. The histology showed that the caudoputamen was either normal or had mild neuronal injury in the 8‐minute group and invariably had some degree of neuronal death in the 15‐, 30‐, and 60‐minute groups, whereas the cortex was either normal or had varying degrees of neuronal injury in all groups. No histological abnormalities were seen in the sham‐operated rats. Our data suggest that acute ADCav reversal does not always predict tissue recovery from ischemic injury and that temporary focal ischemia for even 8‐minute duration can cause delayed neuronal death that is more severe in the caudoputamen where the initial ADCav decline was greater than in the cortex.

Journal

Annals of NeurologyWiley

Published: Sep 1, 1999

References

  • Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging
    Warach, Warach; Gaa, Gaa; Siewert, Siewert
  • Clinical utility of diffusion‐weighted magnetic resonance imaging in the assessment of ischemic stroke
    Lutsep, Lutsep; Albers, Albers; Decrespigny, Decrespigny
  • Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion‐weighted MR imaging and light and electron microscopic study
    Pierpaoli, Pierpaoli; Righini, Righini; Linfante, Linfante
  • Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
    Memezawa, Memezawa; Minamisawa, Minamisawa; Smith, Smith; Siesjö, Siesjö
  • Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia‐ischaemia in the developing brain
    Blumberg, Blumberg; Cady, Cady; Wigglesworth, Wigglesworth
  • Recovery from edema and of protein synthesis differs between the cortex and caudate following transient focal cerebral ischemia in rats
    Abe, Abe; Araki, Araki; Kogure, Kogure

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