1INTRODUCTIONBreast cancer is the most common malignancy and it ranks the first in cancer deaths in females. Adjuvant systemic therapies are used to reduce the risk of death and recurrence by eliminating residual and systemic micrometastases after local control in breast cancer. Disease recurrence is seen in 35–90% of lymph node positive patients and 10–30% of lymph node negative patients who receive only local treatment for occult micrometastatic disease.Selection between local and systemic therapies is done considering the different predictive and prognostic factors. Prognostic factors at the time of diagnosis give information about the course of the disease and the predictive factors give information about the probability of response to treatment that will be given. These factors include tumor histology, tumor size, and axillary lymph node status, hormone receptor status, human epidermal growth factor receptor (HER2) status, other concomitant diseases, age and menopausal status of the patient. Pathological assessment of tumor size, lymph node involvement, proliferation rate (Ki67), tumor grade peritumoral vascular invasion and age, endocrine receptor status, HER2 status of the patient are important predictive factors and guide the way in the choice of adjuvant treatment in early breast cancer. Expression of estrogen receptor (ER) and progesterone receptor
Asia-Pacific Journal of Clinical Oncology – Wiley
Published: Jan 1, 2018
Keywords: ; ;
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