Results of a systematic literature review of treatment modalities for jugulotympanic paraganglioma, stratified per Fisch class

Results of a systematic literature review of treatment modalities for jugulotympanic... KeypointsThis is the First review describing the treatment outcomes of surgery and radiotherapy stratified per Fisch class.For Fisch class A and B tumors surgery is a viable treatment option.For Fisch class c and D tumors radiotherapy results show lower complication rates and similar or better local control rates when compared to the surgical group.Management of jugulotympanic paraganglioma is complex and requires an individualized approach by an experienced team.INTRODUCTIONParagangliomas of the head and neck (HNPs) are rare, comprising about 0.6% of head and neck tumours and 0.03% of all tumours. Thirty per cent of head and neck paragangliomas are jugulotympanic tumours. Jugulotympanic paragangliomas (JTPGL) are slow growing neuro‐endocrine tumours that are benign in almost all cases. Despite the benign nature, symptomatology can be considerable and is mainly caused by growth towards delicate surrounding structures such as cranial nerves (CNs) and large vessels. However, their indolent growth pattern makes it difficult to predict if and when these tumours will become clinically apparent; some tumours cause CN damage or invade the intracranial space, while others show spontaneous regression.It is due to the rarity of paragangliomas and their variable yet potentially debilitating clinical presentation that the management of these tumours remains a matter http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Results of a systematic literature review of treatment modalities for jugulotympanic paraganglioma, stratified per Fisch class

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.13046
Publisher site
See Article on Publisher Site

Abstract

KeypointsThis is the First review describing the treatment outcomes of surgery and radiotherapy stratified per Fisch class.For Fisch class A and B tumors surgery is a viable treatment option.For Fisch class c and D tumors radiotherapy results show lower complication rates and similar or better local control rates when compared to the surgical group.Management of jugulotympanic paraganglioma is complex and requires an individualized approach by an experienced team.INTRODUCTIONParagangliomas of the head and neck (HNPs) are rare, comprising about 0.6% of head and neck tumours and 0.03% of all tumours. Thirty per cent of head and neck paragangliomas are jugulotympanic tumours. Jugulotympanic paragangliomas (JTPGL) are slow growing neuro‐endocrine tumours that are benign in almost all cases. Despite the benign nature, symptomatology can be considerable and is mainly caused by growth towards delicate surrounding structures such as cranial nerves (CNs) and large vessels. However, their indolent growth pattern makes it difficult to predict if and when these tumours will become clinically apparent; some tumours cause CN damage or invade the intracranial space, while others show spontaneous regression.It is due to the rarity of paragangliomas and their variable yet potentially debilitating clinical presentation that the management of these tumours remains a matter

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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