Reply to GATA3 differential expression in neuroblastoma and nephroblastoma

Reply to GATA3 differential expression in neuroblastoma and nephroblastoma We thank our colleagues from the Curie Institute and Stavanger University Hospital for their correspondence, in which they note our recent findings for GATA3 in neuroblastomas and describe their independent assessment. Given our ongoing use of this marker routinely for the support of a neuroblastoma diagnosis, we are reassured that they have extended our reported findings to the observation of positive nuclear staining for GATA3 in all 6 recent consecutive cell block samples of neuroblastomas tested.With respect to Wilms tumors (nephroblastomas), we do not have any experience with GATA3 in cytologic samples. However, we performed a review of our recent surgical pathology samples of Wilms tumors (n = 7; ie, since the time of our starting to use GATA3 as a neuroblastoma marker), the findings of which may help to shed further light on this area. Supporting our colleagues' findings of weak/focal GATA3 expression in 1 of 6 Wilms tumor cell block samples tested, the epithelial component of the Wilms tumors was at least focally positive for GATA3 in 3 of our 7 cases (see Fig. A). Reassuringly, we did not note any blastemal positivity. We have also noticed anecdotally that a substantial subset of normal renal tubules in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Cytopathology Wiley

Reply to GATA3 differential expression in neuroblastoma and nephroblastoma

Loading next page...
 
/lp/wiley/reply-to-gata3-differential-expression-in-neuroblastoma-and-DeRb24kMbq
Publisher
Wiley
Copyright
© 2018 American Cancer Society
ISSN
1934-662X
eISSN
1934-6638
D.O.I.
10.1002/cncy.21953
Publisher site
See Article on Publisher Site

Abstract

We thank our colleagues from the Curie Institute and Stavanger University Hospital for their correspondence, in which they note our recent findings for GATA3 in neuroblastomas and describe their independent assessment. Given our ongoing use of this marker routinely for the support of a neuroblastoma diagnosis, we are reassured that they have extended our reported findings to the observation of positive nuclear staining for GATA3 in all 6 recent consecutive cell block samples of neuroblastomas tested.With respect to Wilms tumors (nephroblastomas), we do not have any experience with GATA3 in cytologic samples. However, we performed a review of our recent surgical pathology samples of Wilms tumors (n = 7; ie, since the time of our starting to use GATA3 as a neuroblastoma marker), the findings of which may help to shed further light on this area. Supporting our colleagues' findings of weak/focal GATA3 expression in 1 of 6 Wilms tumor cell block samples tested, the epithelial component of the Wilms tumors was at least focally positive for GATA3 in 3 of our 7 cases (see Fig. A). Reassuringly, we did not note any blastemal positivity. We have also noticed anecdotally that a substantial subset of normal renal tubules in

Journal

Cancer CytopathologyWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off