Reply to GATA3 differential expression in neuroblastoma and nephroblastoma

Reply to GATA3 differential expression in neuroblastoma and nephroblastoma We thank our colleagues from the Curie Institute and Stavanger University Hospital for their correspondence, in which they note our recent findings for GATA3 in neuroblastomas and describe their independent assessment. Given our ongoing use of this marker routinely for the support of a neuroblastoma diagnosis, we are reassured that they have extended our reported findings to the observation of positive nuclear staining for GATA3 in all 6 recent consecutive cell block samples of neuroblastomas tested.With respect to Wilms tumors (nephroblastomas), we do not have any experience with GATA3 in cytologic samples. However, we performed a review of our recent surgical pathology samples of Wilms tumors (n = 7; ie, since the time of our starting to use GATA3 as a neuroblastoma marker), the findings of which may help to shed further light on this area. Supporting our colleagues' findings of weak/focal GATA3 expression in 1 of 6 Wilms tumor cell block samples tested, the epithelial component of the Wilms tumors was at least focally positive for GATA3 in 3 of our 7 cases (see Fig. A). Reassuringly, we did not note any blastemal positivity. We have also noticed anecdotally that a substantial subset of normal renal tubules in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Cytopathology Wiley

Reply to GATA3 differential expression in neuroblastoma and nephroblastoma

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 American Cancer Society
ISSN
1934-662X
eISSN
1934-6638
D.O.I.
10.1002/cncy.21953
Publisher site
See Article on Publisher Site

Abstract

We thank our colleagues from the Curie Institute and Stavanger University Hospital for their correspondence, in which they note our recent findings for GATA3 in neuroblastomas and describe their independent assessment. Given our ongoing use of this marker routinely for the support of a neuroblastoma diagnosis, we are reassured that they have extended our reported findings to the observation of positive nuclear staining for GATA3 in all 6 recent consecutive cell block samples of neuroblastomas tested.With respect to Wilms tumors (nephroblastomas), we do not have any experience with GATA3 in cytologic samples. However, we performed a review of our recent surgical pathology samples of Wilms tumors (n = 7; ie, since the time of our starting to use GATA3 as a neuroblastoma marker), the findings of which may help to shed further light on this area. Supporting our colleagues' findings of weak/focal GATA3 expression in 1 of 6 Wilms tumor cell block samples tested, the epithelial component of the Wilms tumors was at least focally positive for GATA3 in 3 of our 7 cases (see Fig. A). Reassuringly, we did not note any blastemal positivity. We have also noticed anecdotally that a substantial subset of normal renal tubules in

Journal

Cancer CytopathologyWiley

Published: Jan 1, 2018

References

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