IntroductionBrain‐derived neurotrophic factor (BDNF) is expressed in the brain, especially in the neuronal cells through activation of intracellular signaling of cyclic‐AMP response element binding protein (CREB). BDNF has been implicated in the progression of neuronal survival, phenotyping differentiation and maintenance of various neurons, as well as neurogenesis. BDNF is also found in the blood, plasma and serum, and it can cross the blood–brain barrier, so it is accepted that the amount of blood BDNF reflects the expression of BDNF change in the brain. It is reported that the serum concentration of BDNF in depressed patients is lower than that of normal healthy people, and treatment with antidepressants reverses the BDNF concentration in patients with ameliorating depression. Furthermore, in Alzheimer's disease, lower serum BDNF levels have also been reported, and were restored by treatment with acetylcholine esterase inhibitors. In contrast, Duman et al. reported that animals housed in an enriched environment with a wheel, tunnels, food that they can seek out and so on have higher BDNF concentrations in the brain than animals housed in a normal environment. As the enriched environment gives animals low stress and good exercise, enhancement of BDNF expression in the brain and neurogenesis are observed.
Geriatrics & Gerontology International – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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