AbbreviationsH3K9‐Acehistone H3 lysine 9 acetylationhAMSCsHuman amniotic membrane‐derived mesenchymal stem cellsHDACihistone deacetylase inhibitorsMTA1metastasis‐associated protein 1NaBuSodium butyrateOIMosteogenic induction mediumIntroductionMesenchymal stem cells (MSCs) are multipotent stromal cells that can be isolated from both embryonic and adult tissue sources, such as bone marrow, adipose tissue, cord blood, Wharton's jelly, amniotic fluid, and placenta (Bianco, ). These cells possess the ability to self‐renew and differentiate into multiple lineages, such as adipocytes, chondroblasts, and osteoblasts, which make them very attractive for regenerative medicine. Among the diverse tissue sources of MSCs, amniotic membrane of the whole placenta represents a great choice, which can be acquired conveniently after delivery without damages to the donor and any ethical issues. Amniotic membrane‐derived MSCs have been isolated from several different species including human and demonstrated to be of self‐renewal and differentiation potential as well as the immunomodulatory properties (Kang et al., ; Seo et al., ; Alikarami et al., ; Cardoso et al., ).Regenerative medicine based on MSCs has made great progress in both cell therapy and tissue engineering (Caplan, ). However, suboptimal in vitro expansion as well as inefficient induction of lineage‐specific differentiation have so far halted the further development of MSCs into therapeutics. In one study by Niemeyer
Cell Biology International – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
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