Regionalized metabolic activity establishes boundaries of retinoic acid signalling

Regionalized metabolic activity establishes boundaries of retinoic acid signalling The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an RA hydroxylase that is expressed differentially during early Xenopus development. In Xenopus embryos, XCYP26 can rescue developmental defects induced by application of exogenous RA, suggesting that the enzymatic modifications introduced inhibit RA signalling activities in vivo. Alterations in the expression pattern of a number of different molecular markers for neural development induced upon ectopic expression of XCYP26 reflect a primary function of RA signalling in hindbrain development. Progressive inactivation of RA signalling results in a stepwise anteriorization of the molecular identity of individual rhombomeres. The expression pattern of XCYP26 during gastrulation appears to define areas within the prospective neural plate that develop in response to different concentrations of RA. Taken together, these observations appear to reflect an important regulatory function of XCYP26 for RA signalling; XCYP26‐mediated modification of RA modulates its signalling activity and helps to establish boundaries of differentially responsive and non‐responsive territories. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

Regionalized metabolic activity establishes boundaries of retinoic acid signalling

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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1093/emboj/17.24.7361
Publisher site
See Article on Publisher Site

Abstract

The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an RA hydroxylase that is expressed differentially during early Xenopus development. In Xenopus embryos, XCYP26 can rescue developmental defects induced by application of exogenous RA, suggesting that the enzymatic modifications introduced inhibit RA signalling activities in vivo. Alterations in the expression pattern of a number of different molecular markers for neural development induced upon ectopic expression of XCYP26 reflect a primary function of RA signalling in hindbrain development. Progressive inactivation of RA signalling results in a stepwise anteriorization of the molecular identity of individual rhombomeres. The expression pattern of XCYP26 during gastrulation appears to define areas within the prospective neural plate that develop in response to different concentrations of RA. Taken together, these observations appear to reflect an important regulatory function of XCYP26 for RA signalling; XCYP26‐mediated modification of RA modulates its signalling activity and helps to establish boundaries of differentially responsive and non‐responsive territories.

Journal

The EMBO JournalWiley

Published: Mar 15, 1999

Keywords: ; ; ;

References

  • Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
    Fujii, H; Sato, T; Kaneko, S; Gotoh, O; Fujii‐Kuriyama, Y; Osawa, K; Kato, S; Hamada, H
  • Convergence of 9‐cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptor
    Kliewer, SA; Umesono, K; Noonan, DJ; Heyman, RA; Evans, RM
  • Function of the retinoic acid receptors (RARs) during development. (I) Craniofacial and skeletal abnormalities in RAR double mutants
    Lohnes, D; Mark, M; Mendelsohn, C; Dollé, P; Dierich, A; Gorry, P; Gansmuller, A; Chambon, P

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