Regional Perfusion of the Equine Carpus for Antibiotic Delivery

Regional Perfusion of the Equine Carpus for Antibiotic Delivery Regional perfusion of carpal tissues by forced intramedullary administration of fluids was evaluated in 10 horses. Results of subtraction radiography after perfusion with a contrast medium demonstrated that perfusate was delivered to the carpal tissues by the venous system. Perfused India ink was distributed uniformly in the antebrachiocarpal and middle carpal synovial membranes. Histologically, the ink was within the venules of the synovial villi. Immediately after perfusion with gentamicin sulfate (1g), the gentamicin concentrations in the synovial fluid and synovial membrane of the antebrachiocarpal joint were 349±240 μg/mL and 358±264 μg/g, respectively. When gentamicin concentrations in the synovial fluid of the antebrachiocarpal joint and serum were measured 0, 0.5, 1, 4, 8, 12, and 24 hours after carpal perfusion, the mean peak gentamicin concentration in the synovial fluid was 589 ± 429 μg/mL. At hour 24, the mean gentamicin concentration in the synovial fluid was 4.8 ± 2.0 μg/mL. The resulting peak gentamicin concentration in the serum was 23.7 ± 14.5 μg/mL immediately after the perfusion; it decreased below the desired trough level of 1 μg/mL between hours 4 and 8. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Surgery Wiley

Regional Perfusion of the Equine Carpus for Antibiotic Delivery

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Publisher
Wiley
Copyright
Copyright © 1992 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0161-3499
eISSN
1532-950X
DOI
10.1111/j.1532-950X.1992.tb00064.x
Publisher site
See Article on Publisher Site

Abstract

Regional perfusion of carpal tissues by forced intramedullary administration of fluids was evaluated in 10 horses. Results of subtraction radiography after perfusion with a contrast medium demonstrated that perfusate was delivered to the carpal tissues by the venous system. Perfused India ink was distributed uniformly in the antebrachiocarpal and middle carpal synovial membranes. Histologically, the ink was within the venules of the synovial villi. Immediately after perfusion with gentamicin sulfate (1g), the gentamicin concentrations in the synovial fluid and synovial membrane of the antebrachiocarpal joint were 349±240 μg/mL and 358±264 μg/g, respectively. When gentamicin concentrations in the synovial fluid of the antebrachiocarpal joint and serum were measured 0, 0.5, 1, 4, 8, 12, and 24 hours after carpal perfusion, the mean peak gentamicin concentration in the synovial fluid was 589 ± 429 μg/mL. At hour 24, the mean gentamicin concentration in the synovial fluid was 4.8 ± 2.0 μg/mL. The resulting peak gentamicin concentration in the serum was 23.7 ± 14.5 μg/mL immediately after the perfusion; it decreased below the desired trough level of 1 μg/mL between hours 4 and 8.

Journal

Veterinary SurgeryWiley

Published: Jul 1, 1992

References

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