Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1

Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading... INTRODUCTIONPatients with multiple sclerosis (MS) are often afflicted with episodic memory impairment and, over the past decade, a growing number of studies have investigated how hippocampal abnormalities might be related to this deficit (Dutta et al., ; Hulst et al., ; Planche et al., ; Sicotte et al., ). Postmortem anatomopathological analyses of MS brains, together with studies on animal models of MS, have described early microglial activation, neuronal loss, synaptic dysfunction and demyelination within different regions of the hippocampus (Dutta et al., ; Papadopoulos et al., ; Planche et al., ). However, the time course of these alterations and the inter‐relations between the different types of cellular modifications during the evolution of the disease remain largely unknown.One way to isolate pathogenic mechanisms within the hippocampal circuit is to study its regional vulnerability (Small, ). Indeed, the hippocampus is composed of distinct subfields whose morphological, cellular, molecular, functional, and connectivity profiles are very different: the dentate gyrus, the cornu ammonis (CA, with subdivisions from CA1 to CA4) and the subiculum. Initially used to study Alzheimer's disease and physiological aging (West, Coleman, Flood, & Troncoso, ), this approach of interrogating differentially the malfunctioning hippocampal circuit has been adapted more recently http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Brain Mapping Wiley

Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1065-9471
eISSN
1097-0193
D.O.I.
10.1002/hbm.23970
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPatients with multiple sclerosis (MS) are often afflicted with episodic memory impairment and, over the past decade, a growing number of studies have investigated how hippocampal abnormalities might be related to this deficit (Dutta et al., ; Hulst et al., ; Planche et al., ; Sicotte et al., ). Postmortem anatomopathological analyses of MS brains, together with studies on animal models of MS, have described early microglial activation, neuronal loss, synaptic dysfunction and demyelination within different regions of the hippocampus (Dutta et al., ; Papadopoulos et al., ; Planche et al., ). However, the time course of these alterations and the inter‐relations between the different types of cellular modifications during the evolution of the disease remain largely unknown.One way to isolate pathogenic mechanisms within the hippocampal circuit is to study its regional vulnerability (Small, ). Indeed, the hippocampus is composed of distinct subfields whose morphological, cellular, molecular, functional, and connectivity profiles are very different: the dentate gyrus, the cornu ammonis (CA, with subdivisions from CA1 to CA4) and the subiculum. Initially used to study Alzheimer's disease and physiological aging (West, Coleman, Flood, & Troncoso, ), this approach of interrogating differentially the malfunctioning hippocampal circuit has been adapted more recently

Journal

Human Brain MappingWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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