INTRODUCTIONPatients with multiple sclerosis (MS) are often afflicted with episodic memory impairment and, over the past decade, a growing number of studies have investigated how hippocampal abnormalities might be related to this deficit (Dutta et al., ; Hulst et al., ; Planche et al., ; Sicotte et al., ). Postmortem anatomopathological analyses of MS brains, together with studies on animal models of MS, have described early microglial activation, neuronal loss, synaptic dysfunction and demyelination within different regions of the hippocampus (Dutta et al., ; Papadopoulos et al., ; Planche et al., ). However, the time course of these alterations and the inter‐relations between the different types of cellular modifications during the evolution of the disease remain largely unknown.One way to isolate pathogenic mechanisms within the hippocampal circuit is to study its regional vulnerability (Small, ). Indeed, the hippocampus is composed of distinct subfields whose morphological, cellular, molecular, functional, and connectivity profiles are very different: the dentate gyrus, the cornu ammonis (CA, with subdivisions from CA1 to CA4) and the subiculum. Initially used to study Alzheimer's disease and physiological aging (West, Coleman, Flood, & Troncoso, ), this approach of interrogating differentially the malfunctioning hippocampal circuit has been adapted more recently
Human Brain Mapping – Wiley
Published: Jan 1, 2018
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