INTRODUCTIONPatients with multiple sclerosis (MS) are often afflicted with episodic memory impairment and, over the past decade, a growing number of studies have investigated how hippocampal abnormalities might be related to this deficit (Dutta et al., ; Hulst et al., ; Planche et al., ; Sicotte et al., ). Postmortem anatomopathological analyses of MS brains, together with studies on animal models of MS, have described early microglial activation, neuronal loss, synaptic dysfunction and demyelination within different regions of the hippocampus (Dutta et al., ; Papadopoulos et al., ; Planche et al., ). However, the time course of these alterations and the inter‐relations between the different types of cellular modifications during the evolution of the disease remain largely unknown.One way to isolate pathogenic mechanisms within the hippocampal circuit is to study its regional vulnerability (Small, ). Indeed, the hippocampus is composed of distinct subfields whose morphological, cellular, molecular, functional, and connectivity profiles are very different: the dentate gyrus, the cornu ammonis (CA, with subdivisions from CA1 to CA4) and the subiculum. Initially used to study Alzheimer's disease and physiological aging (West, Coleman, Flood, & Troncoso, ), this approach of interrogating differentially the malfunctioning hippocampal circuit has been adapted more recently
Human Brain Mapping – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera