(Received 9 September 1971.Accepted 15 September 1971) TRYPTOPHAN hydroxylase, the enzyme involved in the conversion of tryptophan to 5-hydroxytryptophan, has been detected in the brain of rat, guinea pig and cat (GRAHAME-SMITH, GREEN 1964; and 1966;GAL,ARMSTRONG GINSBERG, and 1966;LOVENBERG, JEQUIER SJOERDSMA, and 1967; SAWYER, ICHIYAMA, NAKAMURA, NISHIZUKAHAYAISHI,9 8 . Regional distribution of the enzyme has been and 16) et MCGEER MCGEER, and studied with guinea pig brain (ICHIYAMA af., 1968)and cat brain (PETERS, 1 6 ) No report is available on the developmental change of tryptophan hydroxylase in various 98. regions of brain. The present paper reports the regional distribution as well as developmental change of tryptophan hydroxylase in rat brain. Sprague-Dawley rats were supplied from Simonsen Laboratories, Gilroy, California. For the studies of regional distribution, Sprague-Dawley male rats weighing 180-200 g were used. After decapitation, the brains were removed quickly, dissected according to the method of GLOWINSKI and IVERSEN and frozen on solid CO,. For the studies of the developmental change of tryptophan (1966), hydroxylase, the pregnant Sprague-Dawley rats (10-14 days of pregnancy) were supplied and housed 0 separately. Litters were only used if there were eight-ten pups. Fifteen to 3 infant rats of mixed sexes were
Journal of Neurochemistry – Wiley
Published: Mar 1, 1972
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