INTRODUCTIONAlthough numerous therapeutic approaches for treating cancer have been developed, no breakthrough treatment has emerged, thus limiting improvements in the percentage of deaths due to cancer. However, considerable recent attention has been given to the use of plasmas for treating cancer by irradiation with non‐equilibrium atmospheric‐pressure plasma (NEAPP). Recent reports have demonstrated that NEAPP or CAP kill cancer cells selectively, with minimal impact on normal cells.Methods for both direct and indirect irradiation with NEAPP have been proposed. Iseki et al. reported the selective apoptosis of ovarian cancer cells among normal fibroblasts following direct irradiation with NEAPP. Indirect irradiation has the significant advantage for cancer therapy in that it can affect the micro‐metastasis of cancer cells in organs. For example, Utsumi et al. reported an antitumor effect on chemotherapy‐resistant cells in vitro and in vivo.Cell culture medium irradiated with NEAPP is known as plasma‐activated medium (PAM). Tanaka et al. reported that PAM induces the apoptosis of glioblastoma cells selectively over normal astrocytes. This type of selective targeting of cancer cells is ideally suited to cancer therapy. An antitumor effect of PAM treatment has been reported for a broad range of cancer and cancer cell types. Details regarding the intracellular molecular
Plasma Processes and Polymers – Wiley
Published: Jan 1, 2018
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