Recombinant type Human mastadenovirus D85 associated with epidemic keratoconjunctivitis since 2015 in Japan

Recombinant type Human mastadenovirus D85 associated with epidemic keratoconjunctivitis since... INTRODUCTIONAdenoviral conjunctivitis is a major cause of ocular morbidity worldwide. The severity of adenovirus eye infections ranges from mild subclinical cases to severe cases resulting in visual reduction for weeks or even months. The infection is characterized by serious conjunctival infection, severe discharge, the formation of follicles, and a pseudomembrane, lacrimation, hyperemia, papillary hypertrophy, and lymphadenopathy. Severe infections can also lead to ocular lesions that can last from months to years. Due to the structural stability of the adenoviral capsids, the virus can survive outside of hosts in surfaces for long periods, a characteristic facilitating its spread. Moreover, adenoviral epidemic kiratoconjunctivitis (EKC) is a highly contagious disease found in communal and nosocomial outbreaks, with serious social consequences for both health and economics.Most severe cases of adenoviral EKC are caused by infections of types of Human mastadenovirus D (HAdV‐D) 8, 37, 53, 54, 56, and 64. Type 64 was formerly known as type 19a and recently renamed due to its recombinant origin. Types 8, 37, and 64 have frequently been isolated in EKC outbreaks worldwide since 1954. In contrast, types 53, 54, and 56 were recently characterized as new types product of recombination events. The severity, frequency, and distribution of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Recombinant type Human mastadenovirus D85 associated with epidemic keratoconjunctivitis since 2015 in Japan

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25041
Publisher site
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Abstract

INTRODUCTIONAdenoviral conjunctivitis is a major cause of ocular morbidity worldwide. The severity of adenovirus eye infections ranges from mild subclinical cases to severe cases resulting in visual reduction for weeks or even months. The infection is characterized by serious conjunctival infection, severe discharge, the formation of follicles, and a pseudomembrane, lacrimation, hyperemia, papillary hypertrophy, and lymphadenopathy. Severe infections can also lead to ocular lesions that can last from months to years. Due to the structural stability of the adenoviral capsids, the virus can survive outside of hosts in surfaces for long periods, a characteristic facilitating its spread. Moreover, adenoviral epidemic kiratoconjunctivitis (EKC) is a highly contagious disease found in communal and nosocomial outbreaks, with serious social consequences for both health and economics.Most severe cases of adenoviral EKC are caused by infections of types of Human mastadenovirus D (HAdV‐D) 8, 37, 53, 54, 56, and 64. Type 64 was formerly known as type 19a and recently renamed due to its recombinant origin. Types 8, 37, and 64 have frequently been isolated in EKC outbreaks worldwide since 1954. In contrast, types 53, 54, and 56 were recently characterized as new types product of recombination events. The severity, frequency, and distribution of

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ;

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