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Recent advances in arginine metabolism: roles and regulation of the arginases

Recent advances in arginine metabolism: roles and regulation of the arginases As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its metabolism. It is now becoming apparent that the two isoforms of arginase in mammals play key roles in regulation of most aspects of arginine metabolism in health and disease. In particular, work over the past several years has focused on the roles and regulation of the arginases in vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. As most of these topics have been considered in recent review articles, this review will focus more closely on results of recent studies on expression of the arginases in endothelial and vascular smooth muscle cells, post‐translational modulation of arginase activity and applications of arginase inhibitors in vivo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Recent advances in arginine metabolism: roles and regulation of the arginases

British Journal of Pharmacology , Volume 157 (6) – Jul 1, 2009

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Publisher
Wiley
Copyright
© 2009 The Author. Journal compilation © 2009 The British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.2009.00278.x
pmid
19508396
Publisher site
See Article on Publisher Site

Abstract

As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its metabolism. It is now becoming apparent that the two isoforms of arginase in mammals play key roles in regulation of most aspects of arginine metabolism in health and disease. In particular, work over the past several years has focused on the roles and regulation of the arginases in vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. As most of these topics have been considered in recent review articles, this review will focus more closely on results of recent studies on expression of the arginases in endothelial and vascular smooth muscle cells, post‐translational modulation of arginase activity and applications of arginase inhibitors in vivo.

Journal

British Journal of PharmacologyWiley

Published: Jul 1, 2009

References

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